2024

Saxena, S., Nabel, C. S., Seay, T. W., Patel, P. S., Kawale, A. S., Crosby, C. R., Tigro, H., Oh, E., Heiden, M. G. V., Hata, A. N., Suo, Z., and Zou, L.* (2024) "Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells", Mol. Cell, 84 [Online Access] 

Chu, W.-T., Suo, Z., and Wang, J.* (2024) "Three-metal ion mechanism of cross-linked and uncross-linked DNA polymerase β: a theoretical study", J. Chem. Phys., 160, 155101 [Online Access] 

Zhao, W., Hussen, A., Freudenthal, B.D., Suo, Z. Zhao, L.* (2024) "Mitochondrial Transcription Factor A Has 5'-Deoxyribose Phosphate lyase Activity in vitro", DNA Repair, 137, 103666 [Online Access] 

Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L.,  MISEV Consortium, Théry, C.*, and Witwer, K. W.* (2024) "Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches", J. of Extracellular Vesicles, 13, e12404  (Zucai Suo is a member of MISEV Consortium) [Online Access] 

Hade, M. D., Suire, C. N., and Suo, Z.* (2024) "Significant enhancement of fibroblast migration, invasion, and proliferation by exosomes loaded with human fibroblast growth factor 1", ACS Appl. Mater. Interfaces, 16, 1969-1984  [Online Access] 

2023

Seay, T. W. and Suo, Z.* (2023) "Roles of extracelluar vesicles on the progression and metastasis of hepatocellular carcinoma", Cells, 12, 1879  [Online Access]

Hade, M. D., Suire, C. N., and Suo, Z.* (2023) "An effective peptide-based platform for efficient exosomal loading and cellular delivery of a microRNA", ACS Applied Materials & Interfaces, 15, 3851-3866 [Online Access]

Abdullah M. A. F., McWhirter, S. M., and Suo, Z.* (2023) "Modulation of Kinase Activities In Vitro by Hepatitis C Virus Protease NS3/NS4A Mediated-Cleavage of Key Immune Modulator Kinases", Cells, 12, 406 [Online Access]

Stephenson, A. A., Taggart, D. T., Xu, G., Fowler, J. D., Wu, H., and Suo, Z.* (2022) "The inhibitor of kB kinase β (IKKβ)  phosphorylates IkBα twice in a single binding event through a sequential mechanism", J. Biol. Chem., 299, 102796 [Online Access] 

2022

Kumar, A., Reed, A. J., Zahurancik, W. J., Daskalova, S. M., Hecht, S. M., and Suo, Z.* (2022) "Interlocking activities of DNA polymerase beta in the base excision repair pathway",  Proc. Natl. Acad. Sci. USA., 119 (10) [Online Access]

2021

Hade, M. D., Suire, C. N., and Suo, Z.* (2021) "Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine", Cells, 10(8), 1959. [Online Access] 

Raper, A. T., Maxwell, B., and Suo, Z.* (2021) “Dynamic processing of a common oxidative lesion by the first two enzymes of the base excision repair pathway”, J. Mol. Biol., 433:166811. [Online Access] 

Stephenson, A. A., Cao, S., Taggart, D. T., Vyavahare, V. P., and Suo, Z.* (2021) "Design, Synthesis, and Evaluation of Liver-Specific Gemcitabine Prodrugs for Potential Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma", E. J. Med. Chem., 213:113135.  [Online Access] 

2020

Chu, X., Suo, Z., Wang, J.* (2020) "Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase", eLife, 9:e60434  [Online Access] 

Zahurancik, W. J. and Suo, Z.* (2020) "Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase epsilon holoenzyme", J. Biol. Chem., 295, 17251-17264. [Online Access] 

Galati, M., Hodel, K., Gams, M., Sudhaman, S., Bridge, T., Zahurancik, W. J., Ungerleider, N., Park, V., Ercan, A., Joksimovic, L., Siddiqui, I., Siddaway, R., Edwards, M., de Borja, R., Elshaer, D., Chung, J., Forster, V., Nunes, N., Aronson, M., Wang, X., Ramdas, J., Seeley, A., Sarosiek, T., Dunn, G., Byrd, J., Mordechai, O., Durno, C., Martin, A., Shlien, A., Bouffet, E., Suo, Z., Jackson, J., Hawkins, C., Guidos, C., Pursell, Z. F.*, and Tabori, U.* (2020) “Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade”, Cancer Research, 80, 5606–5618  [Online Access] 

Chu, W.-T., Suo, Z.,Wang, J.* (2020) "Binding-Induced Conformational Changes Involved in Sliding Clamp PCNA and DNA Polymerase DPO4", iScience, 23(5), 101117 [Online Access] 

Hodel, K. P., Sun, M. J. S., Ungerleider, N., Park, V. S., Williams, L. G., Bauer, D. L., Immethun, V. E., Wang, J., Suo, Z., Lu, H., McLachlan, J. B., and Pursell Z. F. (2020) “POLE mutation spectra are shaped by the mutant allele identity, its abundance and mismatch repair status”, Mol. Cell, 78(6), 1166-1177.  [Online Access]

Our recently published article "Discovering How Drugs Combat HIV and Why Resistance Can Occur"  has been highlighted in Drug Target Review.

Chu, X., Suo, Z., Wang, J.* (2020) "Confinement and Crowding Effects on Folding of a Multi-domain Y-family DNA Polymerase", J. Chem. Theory Comput. 16(2), 1319-1332

2019

Hung, M., Tokarsky, E. J., Lagpacan, L., Zhang, L., Suo, Z.*, and Lansdon, E. B.* (*Co-Corresponding authors) (2019) Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance. Nature Communication Biology,  PMID: 31872074, PMCID: PMC6910994, DOI: 10.1038/s42003-019-0706-x [Nature Comm. Bio. link], [Press Release]

Phi, Kenneth; Smith, Madison; Tokarsky, E. John; Suo, Zucai. (2019) Kinetic Investigation of Translesion Synthesis across a 3-Nitrobenzanthrone-Derived DNA Lesion Catalyzed by Human DNA Polymerase Kappa. Chemical Research in Toxicology  32(8), 1699-1706.

2018

Our recent article "Sharpening the Scissors: Mechanistic Details of CRISPR/Cas9 Improve Functional Understanding and Inspire Future Research" has been highlighted in JACS spotlight.

Raper, A.T., Stephenson, A.A., and Suo, Z.* (2018) Sharpening the Scissors: Mechanistic Details of CRISPR/Cas9 Improve Functional Understanding and Inspire Future Research. J. Am. Chem. Soc. 140 (36), pp 11142–1115

Raper, A. T., Reed, A. J., and Suo, Z.* (2018) Kinetic Mechanism of DNA Polymerases: Contribution of Conformational Dynamics and a Third Divalent Metal Ion. Chem. Rev. 118 (12), 6000-6025. [Online Access]

Gadkari, V. V., Harvey, S.R., Raper, A.T., Chu, W., Wang, J., Wysocki, V.H., and Suo, Z.* (2018) Investigation of Sliding DNA Clamp Dynamics by Single-Molecule Fluorescence, Mass Spectrometry, and Structure-Based Modeling. Nucleic Acids Research. 46, 3103-3118. [Online Access]

Stephenson, A.A., Raper, A.T., and Suo, Z.* (2018) Bidirectional Degradation of DNA Cleavage Products Catalyzed by CRISPR/Cas9. J. Am. Chem. Soc. 140, 3743-3750. [Online Access][Press Release] [JACS Spotlight]

Raper, A.T., Stephenson, A.A., and Suo, Z.* (2018) Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9. J. Am. Chem. Soc. 140, 2971-2984. [Online Access] [Press Release][JACS Spotlight] [F1000 Recommendation]

Kimsey, I. J., Szymanski, E. S., Zahurancik, W. J., Shakya, A., Xue, Y., Chu, C.-C., Sathyamoorthy, B., Suo, Z.*, and Al-Hashimi, H. M.* (2018) Dynamic basis for dG•dT misincorporation via tautomerization and ionization. Nature (Article) 554, 195-201. (*Co-Corresponding authors)  [Online Access]  [OSU Press Release] [Duke Press Release][Myron Goodman Commentary in Nature][F1000 Recommendation]

2017

Campbell, B.B., Light, N., Fabrizio, D., Zatzman, M., Fuligni, F., de Borja, R., Davidson, S., Edwards, M., Elvin, J.A., Hodel, K.P., Zahurancik, W.J., Suo, Z., Lipman, T., Wimmer, K., Kratz, C.P., Bowers, D.C., Laetsch, T.W., Dunn, G.P., Johanns, T.M., Grimmer, M.R., Smirnov, I.V., Larouche, V., Samuel, D., Bronsema, A., Osborn, M., Stearns, D., Raman, P., Cole, K.A., Storm, P.B., Yalon, M., Opocher, E., Mason, G., Thomas, G.A., Sabel, M., George, B., Ziegler, D.S., Lindhorst, S., Issai, V.M., Constantini, S., Toledano, H., Elhasid, R., Farah, R., Dvir, R., Dirks, P., Huang, A., Galati, M.A., Chung, J., Ramaswamy, V., Irwin, M.S., Aronson, M., Durno, C., Taylor, M.D., Rechavi, G., Maris, J.M., Bouffet, E., Hawkins, C., Costello, J.F., Meyn, M.S., Pursell, Z.F., Malkin, D., Tabori, U., and Shlien, A. (2017) Comprehensive analysis of hypermutation in human cancer. Cell. 171, 1042-1056. [Online Access] [Commentary in Cell]

Reed, A.J., and Suo, Z. (2017) Time-Dependent Extension from an 8?Oxoguanine Lesion by Human DNA Polymerase Beta. J. Am. Chem. Soc. 139, 9684-9690. [Online Access]

Lee, E., Fowler, J.D., Suo, Z., and Wu, Z.* (2017) Backbone Assignment of the Binary Complex of the Full Length Sulfolobus solfataricus DNA Polymerase IV and DNA. Biomolecular NMR Assignments, 11, 39-43. [Online Access]

Wu, J., Wang, P., Li, L., Williams, N.L., Ji, D., Zahurancik, W.J., You, C., Wang, J., Suo, Z., Wang, Y. (2017) Replication studies of carboxymethylated DNA lesions in human cells. Nucleic Acids Research. 45 (12), 7276-7284. [Online Access]

Vyas, R., Reed, A.J.,  Raper, A.T., Zahurancik, W.J., Wallenmeyer, P.C., and Suo, Z. (2017) Structural basis for the D-stereoselectivity of human DNA polymerase β. Nucleic Acids Research. 45 (10), 6228-6237. [Online Access]

Gowda, A.S.P., Krzeminski, J., Amin, S., Suo, Z., Spratt, T.E. Mutagenic Replication of N2-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase I and Sulfolobus solfataricus DNA Polymerase IV. Chem. Res. Toxicol. 30, 1168-1176. [Online Access]

Stephenson, A.A., Taggart, D.J., Suo, Z.* (2017) Non-catalytic, N-terminal Domains of DNA Polymerase Lambda Affect Its Cellular Localization and DNA Damage Response. Chem. Res. Toxicol. 30, 1240-1249. [Online Access]

Gowda, P., Suo, Z., and Spratt, T.E. (2017) Honokiol inhibits DNA polymerases β and λ and increases bleomycin sensitivity of human cancer cells. Chem. Res. Toxicol. 30, 715-725. [Online Access]

Wang, Y., Jin, F., Wang, Q., and Suo, Z.* (2017) Long-term survival of AIDS patients treated with only traditional Chinese medicine. AIDS Res. Hum. Retroviruses. 33, 90-92. [Online Access] [Press Release 1, 2, 3, 4, 5, and 6] [Highlighted in Editorial] [ACS TOXI Division Tweet]

Raper, A.T., Reed, A.J., Gadkari, V.V., and Suo, Z.* (2017) Advances in Structural and Single-Molecule Methods for Investigating DNA Damage Tolerance and Repair. Chem. Res. Toxicol. 30, 260-269. [Online Access]

Reed, A.J., Vyas, R., Raper, A.T., and Suo, Z.* (2017) Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase. J. Am. Chem. Soc. 139, 465-471. [Online Access]

Tokarsky, E.J., Wallenmeyer, P.C., Phi, K.K., and Suo, Z.* (2017) Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol. DNA Repair. 49, 51-59. [Online Access]

2016

Raper, A. T. and Suo, Z.* (2016) Investigation of Intradomain Motions of a Y-Family DNA Polymerase during Substrate Binding and Catalysis. Biochemistry. 55, 5832-5844. [Online Access]

Tokarsky, E.J., Gadkari, V.V., Zahurancik, W.J., Malik, C.K., Basu, A.K., and Suo, Z.* (2016) Pre-Steady-State Kinetic Investigation of Bypass of a Bulky Guanine Lesion by Human Y-family DNA Polymerases. DNA Repair, 46, 20-28. [Online Access]

Patra, A., Politica, D.A., Chatterjee, A., Tokarsky, E.J., Suo, Z., Basu, A.K., Stone, M.P., and Egli, M.* (2016) Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2- Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase. ChemBioChem. 17(21), 2033-2037. [Online Access]

Raper, A.T., Gadkari, V.V., Maxwell, B.A., and Suo, Z.* (2016) Single-Molecule Investigation of Response to Oxidative DNA Damage by a Y-Family DNA Polymerase. Biochemistry. 55(14), 2187-2196. [Online Access]

2015

Vyas, R., Efthimiopoulos, G., Tokarsky, E.J., Malik, C.K., Basu, A.K., and Suo, Z.* (2015) Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase. J. Am. Chem. Soc. 137 (37), 12131-12142. [Online Access] [Highlighted in F1000Prime]

Vyas, R., Reed, A.J., Tokarsky, E.J., and Suo, Z.* (2015) Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography. J. Am. Chem. Soc. 137 (15), 5225-5230. [Online Access] [Highlighted in F1000Prime] [OSU Press Release] [APS Highlight]

Dunn, M.R., Larsen, A.C., Zahurancik, W.J., Fahmi, N.E., Meyers, M., Suo, Z., and Chaput, J.C.* (2015) Therminator-Mediated Synthesis of Unbiased TNA Polymers Requires 7-Deazaguanine to Suppress G-G Mispairing during TNA Transcription. J. Am. Chem. Soc. 137 (12), 4014-4017. [Online Access]

Zahurancik, W. J., Baranovskiy, A.G., Tahirov, T.H., and Suo, Z.* (2015) Comparison of the Kinetic Parameters of the Truncated Catalytic Subunit and Holoenzyme of Human DNA Polymerase  ε. DNA Repair. 29, 16-22. [Online Access]

2014

Zahurancik, W. J., Klein, S.J., and Suo, Z.* (2014) Significant Contribution of the 3’→5′ Exonuclease Activity to the High Fidelity of Nucleotide Incorporation Catalyzed by Human DNA Polymerase ε. Nucleic Acids Research. 42 (22), 13853-60. [Online Access] 

Gaur, V., Vyas, R., Fowler, J.D., Efthimiopoulos, G., Feng, J., and Suo, Z.* (2014) Structural and Kinetic Insights into Binding and Incorporation of L-Nucleotide Analogs by a Y-family DNA Polymerase. Nucleic Acids Research. 42 (15), 9984-95. [Online Access]

Taggart, D.J., Dayeh, D.M., Fredrickson, S.W., and Suo, Z.* (2014) N-terminal Domains of Human DNA Polymerase Lambda Promote Primer Realignment during Translesion DNA Synthesis. DNA Repair. 22C, 41-52. [Online Access]

Chu, X., Liu, F., Maxwell, B.A., Wang. Y., Suo, Z., and Wang, J.* (2014) Dynamic conformational change regulates the protein-DNA recognition: An investigation on binding of a Y-family polymerase to its target DNA. PLOS Computational Biology. 10 (9), 1-15. [Online Access]

Vyas, R., Zahurancik, W.J., and Suo, Z.* (2014) Structural Basis for the Binding and Incorporation of Nucleotide Analogs with L-Stereochemistry by Human DNA Polymerase λ. PNAS PLUS. 111 (30), E3033-42 . [Online Access]

Gadkari, V.V., Tokarsky, E.J., Malik, C.K., Basu, A.K., and Suo, Z.* (2014) Mechanistic Investigation of the Bypass of a Bulky Aromatic DNA Adduct Catalyzed by a Y-Family DNA Polymerase. DNA Repair. 21, 65-77. [Online Access]

Xu, C., Maxwell, B.A., and Suo, Z.* (2014) Conformational Dynamics of Thermus aquaticus DNA Polymerase I during Catalysis. J. Mol. Biol. 426 (16), 2901-2917. [Online Access]

Taggart, D.J., Fredrickson, S.W., Gadkari, V.V., and Suo, Z.* (2014) Mutagenic Potential of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass Catalyzed by Human Y-family DNA Polymerases. Chem. Res. Toxicol. 27 (5), 931-940. [Online Access]

Maxwell, B.A., Xu, C., and Suo, Z.* (2014) Conformational dynamics of a Y-Family DNA polymerase during substrate binding and catalysis as revealed by inter-domain Förster resonance energy transfer. Biochemistry. 53 (11), 1768-1778. [Online Access]

Maxwell, B.A., and Suo, Z.* (2014) Recent Insight into the Kinetic Mechanisms and Conformational Dynamics of Y-Family DNA Polymerases. Biochemistry. 53 (17), 2804-2814. [Online Access]

2013

Qin Y., Yang Y., Zhang L., Fowler J.D., Qiu W., Wang L. Suo Z., Zhong D.* (2013) Direct Probing of Solvent Accessibility and Mobility at the Binding Interface of Polymerase (Dpo4)-DNA Complex. J. Phys. Chem. A. 117, 13926−13934. [Online Access]

Zahurancik, W.J., Klein, S.J., Suo, Z.* (2013) Kinetic Mechanism of DNA Polymerization Catalyzed by Human DNA Polymerase ε. Biochemistry. 52, 7041−7049. [Online Access].

Espinoza Herrera, S., Gaur, V., Suo, Z., Carey, P.* (2013) Following DNA chain extension and protein conformational changes in crystals of a Y-family DNA polymerase by Raman crystallography. Biochemistry. 52, 4881−4890. [Online Access]

Maxwell, B.A., Suo, Z.* (2013) Single-Molecule Investigation of Substrate Binding Kinetics and Protein Conformational Dynamics of a B-Family Replicative DNA Polymerase. J. Biol. Chem. 288, 11590-11600. [Online Access]

Taggart, D.J., Camerlengo, T.L., Harrison, J.K., Sherrer, S.M., Kshetry, A.K., Taylor, J., Huang, K., Suo, Z.* (2013) A High-Throughput and Quantitative Method to Assess the Mutagenic Potential of Translesion DNA. Nucleic Acids Research. 41, e96.[Online Access]

2012

Gokesenin, A.Y., Zahurancik, W., LeCompte, K.G., Taggart, D.J., Suo, Z. and Pursell, Z.F.* (2012) Human DNA Polymerase Epsilon Is Able to Efficiently Extend from Multiple Consecutive Ribonucleotides. J. Biol. Chem. 287, 42675-42684. [Online Access]

Sherrer, S.M., Taggart, D.J., Pack, L.R., Malik, C.K., Basu, A.K, and Suo, Z.* (2012) Quantitative Analysis of the Mutagenic Potential of 1-Aminopyrene-DNA Adduct Bypass Catalyzed by Y-Family DNA Polymerases. Mutat. Res. 737, 25-33. [Online Access]

Wang, Y., Chu, X., Suo, Z., Wang, E., Wang, J.* (2012) Multi-domain Protein Solves the Folding Problem by Multi-funnel Combined Landscape: Theoretical Investigation of a Y-Family DNA Polymerase. JACS. 134 (33), 13755-13764. [Online Access]

Sherrer, S.M., Maxwell, B.A., Pack, L.R., Fiala, K.A., Fowler, J.D., Zhang, J. and Suo, Z.* (2012) Identification of an Unfolding Intermediate for a DNA Lesion Bypass Polymerase. Chem. Res. Toxicol. 25 (7), 1531-1540. [Online Access]

Gowda, A.P., Krishnegowda, G., Suo, Z., Amin, S. and Spratt, T.E.* (2012) Low Fidelity Bypass of O2-(3-Pyridyl)-4-oxobutylthymine, the Most Persistent Bulky Adduct Produced by the Tobacco Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by Model DNA Polymerases. Chem. Res. Toxicol. 25 (6), 1195-1202. [Online Access]

Maxwell, B.A., and Suo, Z.* (2012) Kinetic Basis for Differing Response to an Oxidative Lesion by a Replicative and a Lesion Bypass DNA Polymerase from Sulfolobus Solfataricus. Biochemistry. 51, 3485−3496. [Online Access]

Maxwell, B.A., Xu, C., and Suo, Z.* (2012) A DNA Lesion Alters the Global Conformational Dynamics of a Y-Family DNA Polymerase during Catalysis. J. Biol. Chem. 287 (16), 13040–13047. [Online Access]

Sherrer, S.M., Sanman, L.E., Xia, C.X., Bolin, E.R., Malik, C.K., Efthimiopoulos, G., Basu, A.K., and Suo, Z.* (2012) Kinetic Analysis of the Bypass of a Bulky DNA Lesion Catalyzed by Human Y-family DNA Polymerases. Chem. Res. Toxicol. 25, 730-740.[Online Access]

Song, Q., Sherrer, S.M., Suo, Z., and Taylor, J.-S. (2012) Preparation of a site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase eta. J. Biol. Chem. 287(11), 8021-8028. [Online Access]

Brown, J.A., Pack, L.R., Fowler, J.D., and Suo, Z.* (2012) Pre-Steady State Kinetic Investigation of the Incorporation of Anti-Hepatitis B Nucleotide Analogs Catalyzed by Non-Canonical Human DNA Polymerases. Chem. Res. Toxicol. 25, 225-233.[Online Access]

2011

Ma, D., Fowler, J.D., and Suo, Z.* (2011) Backbone Assignment of the Little Finger Domain of a Y-Family DNA Polymerase. Biomolecular NMR Assignments. 5(2), 195-198.[Online Access]

Kirouac, K.N., Suo, Z., and H. Ling* (2011) Structural mechanism of ribonucleotide discrimination by a Y family DNA polymerase. J. Mol. Biol. 407(3), 382-390. [Online Access]

Brown, J.A. and Suo, Z.* (2011) Unlocking the Sugar ‘Steric Gate’ of DNA Polymerases. Biochemistry, invited review 50, 1135-1142. [Online Access][Article Featured on Biochemistry Jounal Homepage]

Brown, J.A., Pack, L.R., Fowler, J.D. and Suo Z.* (2011) Pre-Steady State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-family DNA Polymerases, Antimicrob. Agents Chemother. 55, 276-283. [Online Access][Press Release]

Brown, J.A., Pack, L.R., Sanman, L.E. and Suo Z.* (2011) Efficiency and Fidelity of Human DNA Polymerases Lambda and Beta during Gap-Filling DNA Synthesis, DNA Repair 10, 24-33. [Online Access]

Sherrer S.M., Fiala, K.A., Fowler J.D., Newmister, S.A., Pryor, J.M. and Suo Z.* (2011) Quantitative Analysis of the Efficiency and Mutagenic Spectra of Abasic Lesion Bypass Catalyzed by Human Y-family DNA Polymerases, Nucleic Acids Research 39, 609–622. [Online Access] (SI)

2010

Sherrer S.M., Beyer, D.C., Xia, C.X., Fowler J.D., and Suo Z.* (2010) Kinetic Basis of Sugar Selection by a Y-family DNA Polymerase from Sulfolobus solfataricus P2, Biochemistry 49, 10179-10186. [Online Access] (SI)

Brown, J.A., Pack, L.R., Sherrer, S.M., Kshetry, A.K., Newmister, S.A., Fowler, J.D., Taylor, J.-S. and Suo Z.* (2010) Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase Lambda, J. Mol. Biol. 403, 505-515. [Online Access] (SI)

Ma, D., Fowler, J.D., Yuan, C. and Suo Z.* (2010) Backbone Assignment of the Catalytic Core of a Y-family DNA Polymerase, Biomolecular NMR Assignments 4, 207-209 DOI: 10.1007/s12104-010-9244-7. [Online Access]

Brown, J.A., Fowler, J.D. and Suo Z.* (2010) Kinetic Basis of Nucleotide Selection Employed by a Protein Template-Dependent DNA Polymerase, Biochemistry 49, 5504-5510. [Online Access]

Wong, J.H., Brown, J.A., Suo Z., Blum, P., Nohmi, T. and Ling, H.* (2010) Structural Insight into Dynamic Bypass of the Major Cisplatin-DNA Adduct by Y-family Polymerase Dpo4, EMBO J. 29, 2059-2069. [Online Access] (SI)

Brown, J.A., Zhang, L., Sherrer, S.M., Taylor, J.-S., Burgers, P.M.J. and Suo Z.* (2010) Pre-Steady State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta, J. Nucleic Acids 2010, 11 pages. (Online Access)

Brown, J.A., Fiala, K.A., Fowler, J.D., Sherrer, S.M., Newmister, S.A., Duym, W.W. and Suo Z.* (2010) A Novel Mechanism of Sugar Selection Utilized by a Human X-family DNA Polymerase, J. Mol. Biol. 395, 282-290. (Online Access) (SI)

2009

Xu, C., Maxwell, B.A., Brown, J.A., Zhang, L. and Suo Z.* (2009) Global Conformational Dynamics of a Y-family DNA Polymerase during Catalysis, PLoS Biology 7(10): e1000225. (Online Access) [Press Release] [Highlighted in F1000Prime]

Brown, J.A. and Suo Z.* (2009) Elucidating the Kinetic Mechanism of DNA Polymerization Catalyzed by Sulfolobus solfataricus P2 DNA Polymerase B1, Biochemistry 48, 7502-7511. (Online Access) (SI)

Zhang, L., Brown, J.A., Newmister, S.A. and Suo Z.* (2009) Polymerization Fidelity of a Replicative DNA Polymerase from the Hyperthermophilic Archaeon Sulfolobus solfataricus P2, Biochemistry 48, 7492-7501. (Online Access) (SI)

Fowler J.D., Brown, J.A., Kvaratskhelia, M. and Suo Z.* (2009) Probing Conformational Changes of Human DNA Polymerase Lambda using Mass Spectrometry-Based Protein Footprinting, J. Mol. Biol. 390, 368-379. (Online Access) (SI)

Sherrer S.M., Brown J.A., Pack L.R., Jasti V.P., Fowler J.D., Basu A.K., and Suo Z.* (2009) Mechanistic Studies of the Bypass of a Bulky Single-Base Lesion Catalyzed by a Y-family DNA Polymerase, J. Biol. Chem. 284, 6379-8863. (Online Access) (SI)

2008

DeCarlo, L., Prakasha Gowda, A.S., Suo, Z. and Spratt, T.E.* (2008) Formation of Purine-Purine Mispairs by Sulfolobus solfataricus DNA Polymerase IV, Biochemistry 47, 8157-8164. (Online Access) (SI)

Brown, J.A., Newmister, S.A., Fiala, K.A. and Suo, Z.* (2008) Mechanism of Double-Base Lesion Bypass Catalyzed by a Y-family DNA Polymerase, Nucleic Acids Research 36, 3867-3878. (Online Access) (SI)

Wong, J.H., Fiala, K.A., Suo, Z. and Ling, H.* (2008) Snapshots of a Y-family DNA Polymerase in Replication: Substrate-Induced Conformational Transitions and Implications for Fidelity of Dpo4, J. Mol. Biol. 379, 317-330. (Online Access)

Fowler, J.D., Brown, J.A., Johnson, K.A. and Suo, Z.* (2008) Kinetic Investigation of the Inhibitory Effect of Gemcitabine on DNA Polymerization Catalyzed by Human Mitochondrial DNA Polymerase. J. Biol. Chem. 283, 15339-15348. (Online Access) (SI)

Fiala, K.A., Sherrer, S.M., Brown, J.A. and Suo, Z.* (2008) Mechanistic Consequences of Temperature on DNA Polymerization Catalyzed by a Y-family DNA Polymerase, Nucleic Acids Research 36, 1990-2001. (Online Access) (SI)

2007

Brown, J.A., Duym, W.W., Fowler, J.D. and Suo, Z.* (2007) Single-Turnover Kinetic Analysis of the Mutagenic Potential of 7,8-Dihydro-8-oxoguanine during Gap-Filling Synthesis Catalyzed by Human DNA Polymerases Lambda and Beta, J. Mol. Biol. 367, 1258-1269. (Online Access)

Fiala, K.A., Brown, J.A., Ling, H., Kshetry, A.K., Zhang, J., Taylor, J.S., Yang, W. and Suo, Z.* (2007) Mechanism of Template-Independent Nucleotide Incorporation Catalyzed by a Template-Dependent DNA Polymerase, J. Mol. Biol. 365, 598-610. (Online Access)

Fiala, K.A., Hypes, C. and Suo, Z.* (2007) Mechanism of Abasic Lesion Bypass Catalyzed by a Y-family DNA Polymerase, J. Biol. Chem. 282, 8188-8198. (Online Access) (SI) [Press Release]

Fiala, K.A. and Suo, Z.* (2007) Sloppy Bypass of an Abasic Lesion Catalyzed by a Y-family DNA Polymerase. J. Biol. Chem. 282, 8199-8206. (Online Access) (SI) [Press Release]

Abdullah, M.A.F. and Suo, Z.* (2007) Unique Composite Active Site of the Hepatitis C Virus NS2-3 Protease: A New Opportunity for Antiviral Drug Design. Chem. Med. Chem. 2, 283-284. (Online Access)

2006

Duym, W.W., Fiala, K.A., Bhatt N. and Suo, Z.* (2006) Kinetic Effect of a Downstream Strand and Its 5′-Terminal Moieties on Single-Nucleotide Gap-Filling Synthesis Catalyzed by Human DNA Polymerase Lambda. J. Biol. Chem. 281, 35649-35655. (Online Access)

Fiala, K.A., Duym, W.W., Zhang, J. and Suo, Z.* (2006) Up-regulation of the Fidelity of Human DNA Polymerase Lambda by Its Non-enzymatic Proline-rich Domain, J. Biol. Chem. 281, 19038-44. (Online Access) [Press Release]

Fowler, J.D. and Suo, Z.* (2006) Biochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase. Chem. Rev., 106(6), 2092-110. (Online Access)

2005

Suo, Z.* (2005) Thioesterase Portability and Peptidyl Carrier Protein Swapping in Yersiniabactin Synthetase from Yersinia pestis. Biochemistry 44, 4926-4938. (Online Access)

Johnson, A.A., Fiala, K.A. and Suo, Z.* (2005) Chapter 6: DNA Polymerases and Their Interactions with DNA and Nucleotides, pp133-168. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Abdel-Gawad, W., Tan, S. L. and Suo, Z.* (2005) Chapter 7: RNA polymerases, pp169-206. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Wang, L. and Suo, Z.* (2005) Chapter 8: Reverse Transcriptase, pp207-246. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

2004

Fiala, K.A. and Suo, Z.* (2004) Pre-Steady State Kinetic Studies of the Fidelity of Sulfolobus solfataricus P2 DNA Polymerase IV, Biochemistry 43, 2106-2115. (Online Access)

Fiala, K.A. and Suo, Z.* (2004) Mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA Polymerase IV, Biochemistry 43, 2116-2125. (Online Access)

Zhang G. and Suo, Z.* (2004) A Mild and Convenient Synthetic Method for Arylhydrazones of Methyl Benzoate, Synthetic Communications 34 (4), 673-678.

Fiala, K.A., Abdel-Gawad, W. and Suo, Z.* (2004) Pre-Steady-State Kinetic Studies of the Fidelity and Mechanism of Polymerization Catalyzed by Truncated Human DNA Polymerase Lambda, Biochemistry 43, 6751-6762. (Online Access)

Roettger, M.P., Fiala, K.A. and Suo. Z.* (2004) Fidelity of Human DNA Polymerase Mu, Biochemistry 43, 13827-13838. (Online Access)

2001

Allison, A.J., Ray, A., Suo, Z., Colacino, J.M., Andeson, K.S. and Johnson, K.A. (2001) Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase, J. Biol. Chem. 276, 40847-40857.

Suo, Z., Tseng, C. and Walsh, C.T. (2001) Purification, Priming, and Catalytic Acylation of Carrier Protein Domains in the Polyketide Synthase and Nonribosomal Peptidyl Synthetase Modules of the HMWP1 Subunit of Yersiniabactin Synthetase, Proc. Natl. Acad. Sci. U.S.A. 98, 99-104.

2000

Suo, Z., Chen, H. and Walsh, C. T. (2000) Acyl CoA Hydrolysis by the HMWP1 Subunit of Yersiniabactin Synthetase: Mutational Evidence for A Cascade of Four Acyl-Enzyme Intermediates during Hydrolytic Editing, Proc. Natl. Acad. Sci. U.S.A. 97, 14188-14193.

Keating, T.A., Suo, Z., Ehmann, D.D. and Walsh, C.T. (2000) Selectivity of the Yersiniabactin Synthetase Adenylation Domain in the Two Step Process of Amino Acid Activation and Transfer to a Holo-Carrier Protein, Biochemistry 39, 2297-2306.