The Suo Research Lab

2014-methods-collage

Dr. Zucai Suo

Eminent Professor
Dorian and John Blackmon Chair in Biomedical Science

Department of Biomedical Sciences
College of Medicine
Florida State University
Tallahassee, FL 32306-4300
Telephone: 850-645-2501
Email: zucai.suo@med.fsu.edu

 

Available Postdoctoral Positions

Employer: Florida State University College of Medicine

Location: Tallahassee, Florida

Salary: NIH guidelines for post-doctoral salaries + benefits

Discipline: Life Sciences, Biochemistry, Biology, Biophysics, Structural Biology, and Biomedical Sciences

Position Type: Full Time

Organization Type: Academia

Job Type: Postdoc

Three Available Postdoctoral Positions in an Enzymology Laboratory

Postdoctoral Positions in Mechanistic Enzymology: Three postdoctoral positions are available immediately in an enzymology laboratory to elucidate mechanisms of DNA/RNA synthesis, DNA lesion bypass, and base excision repair catalyzed by various human and viral DNA/RNA polymerases, and to mechanistically investigate gene editing enzymes including CRISPR/Cas9 and Cas13a. Background in enzyme kinetics (single molecule, stopped-flow and rapid chemical quench measurements, data analysis, etc.), enzyme dynamics, structural biology, biochemistry, biophysics, protein purification, and recombinant DNA techniques is preferred. An important criterion for selection will be the ability of the desired individual to pursue independent research in an active multi-disciplinary setting. Interested candidates should send a CV and a statement describing experience, goals, and reasons for the interest in this position, and arrange to have three letters of recommendation sent to: Dr. Zucai Suo, Eminent Professor and Dorian and John Blackmon Chair of Biomedical Science, Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL. Dr. Suo can be contacted by email (zucai.suo@med.fsu.edu). Further information about the research projects in the Suo Lab can be obtained from here.

 

Postdoctoral Position in Single Molecule Enzymology

One postdoctoral position is available immediately in an enzymology laboratory to elucidate the kinetics and dynamics of DNA lesion bypass and base excision repair catalyzed by human enzymes using single molecule Prism-based Total Internal Reflection Fluorescence (TIRF) apparatus. Background in single molecule TIRF technologies, computer programming, enzyme kinetics, biophysics, and protein purification is preferred. An important criterion for selection will be the ability of the desired individual to pursue independent research in an active multi-disciplinary setting. Interested candidates should send a cover letter, CV, and arrange to have three letters of recommendation sent to: Dr. Zucai Suo, Eminent Professor and Dorian and John Blackmon Chair of Biomedical Science, Department of Biomedical Sciences, College of Medicine, Florida State University. Dr. Suo can be contacted by email (zucai.suo@med.fsu.edu) or phone (850-645-2501). Further information about the research projects in the Suo Lab can be obtained from here.

 

Recent News, Awards, and Recognition

FSU’s Office of the Vice President for Research awarded faculty members a pot of more than $134,000 for the Spring 2020 GAP Commercialization Investment Program (GAP).  A better way to treat wounds: Zucai Suo, a professor in the Department of Biomedical Sciences, and David Meckes, an associate professor in the Department of Biomedical Sciences, have developed a new way to produce and purify exosomes, which are fluid-filled packages released by cells. [Article]

Our recently published article "Discovering How Drugs Combat HIV and Why Resistance Can Occur"  has been highlighted in Drug Target Review.

In a paper published by Communications Biology , an open-access journal from Nature Research, Professor Zucai Suo and colleagues also provide the key to understanding how a single HIV-1 mutation can inactivate the anti-HIV drugs emtricitabine and lamivudine.[Press Release]

Undergraduate researcher Alice Hamilton has been awarded General Chemistry II award in 2019.

Undergraduate student Kirstie Walters has been awarded Hoffman chemistry and biochemistry scholarship in 2019.

Our recent article "Sharpening the Scissors: Mechanistic Details of CRISPR/Cas9 Improve Functional Understanding and Inspire Future Research" has been highlighted in JACS spotlight.

Media coverage: Office of news source, Florida State University: Moving translational research forward: Noted scientist joins College of Medicine faculty

College of Medicine Spotlight: The Cutting Edge

Dr. Vineet Gaur, a former post-doctoral researcher, has been awarded 2018 Ramalingaswami Re-entry Fellowship by Department of Biotechnology, Government of India, which is given to Indian nationals who have conducted research overseas and demonstrated an excellent publication and achievement track record. The Fellowship provides senior researcher status and stipend for those researchers who are returning to India for faculty positions. Dr. Gaur will be joining National Institute of Plant Genome Research, New Delhi, India in May, 2019.

Our recent publication in JACS, “Functional Insights Revealed by the Kinetic Mechanism of CRISPR/Cas9” has been recommended in F1000Prime. [F1000 Recommendation]

Our recent publications in JACS regarding the mechanism and new activity of CRISPR/Cas9 have been featured in a JACS Spotlight. [JACS Spotlight]

Our recent publication in Nature, “Dynamic basis for dG•dT misincorporation via tautomerization and ionization”, has been recommended in F1000Prime as being of special significance in its field. [F1000 Recommendation]

The Suo lab has recently published two articles in the Journal of the American Chemical Society detailing the kinetic mechanism of CRISPR/Cas9 as well as identifying and characterizing a novel activity of Cas9. [Kinetic Mechanism Publication][New Activity Publication] [Press Release]

Dr. Suo and Walter Zahurancik, in collaboration with Dr. Al-Hashimi’s lab at Duke University, have published a research article in Nature entitled: “Dynamic basis for dG•dT misincorporation via tautomerization and ionization”. [Online Access] [OSU Press Release] [Duke Press Release][Myron Goodman Commentary in Nature]

Dr. Suo and Walter Zahurancik’s publication in Cell, “Comprehensive analysis of hypermutation in human cancer”, has been highlighted in a commentary also published in Cell. [Commentary in Cell]

Our 2017 publication in Aids Research and Human Retroviruses, “Long-term survival of AIDS patients treated with only traditional Chinese medicine”, has become the No. 1 most downloaded publication of that journal in the past 12 months (as of December 2017).

Former Postdoctoral Researcher Dr. Rajan Vyas was awarded the 2017 Ramalingaswami Re-entry Fellowship, which is given to Indian nationals who have conducted research overseas and demonstrated an excellent publication and achievement track record. The Fellowship provides senior researcher status and stipend for those researchers who are returning to India for faculty positions. Dr. Vyas is currently working as Assistant Professor at Central University of Punjab, Bathinda, India.

Dr. Suo has served as the secretary for the Division of Chemical Toxicology of the American Chemical Society since January 2016 and has just been elected to the position of treasurer starting in 2020.

Dr. Suo has been awarded the 2017 Okeanos-CAPA (Chinese-American Chemistry & Chemical Biology Professors Association) Senior Investigator Award.

Former Suo Lab graduate student Dr. Shanen Sherrer has accepted a faculty position at St. Mary’s College of Maryland in the Department of Biochemistry.

Former Suo Lab graduate student Dr. Jessica Brown has accepted a faculty position at the University of Notre Dame in the Department of Chemistry & Biochemistry. [New Faculty Announcement]

Our 2015 publication in JACS, “Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography,” has been featured in the April 26th, 2016 edition of APS Science Highlight. [Online Access]

Access the recommendation on F1000Prime

Our recent publication in JACS, “Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase,” has been recommended in F1000Prime  as being of special significance in its field.

Access the recommendation on F1000PrimeOur recent publication in JACS, “Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography,” has been recommended in F1000Prime  as being of special significance in its field.

Former Suo Lab graduate student Dr. Brian Maxwell has been awarded the George Mitchell Endowed Fellowship from St. Jude Children’s Research Hospital.  This is prestigious award is given to only one Postdoctoral Researcher every year.

Dr. Suo was elected as a Fellow of the American Association for the Advancement of Science (AAAS) for distinguished contributions to the field of nucleic acid enzymology, particularly for pre-steady state kinetic and protein conformational dynamic studies of DNA polymerases. Read more