Publications
Cone AS, York SB, Meckes DG Jr. Extracellular Vesicles in Epstein-Barr Virus Pathogenesis. Curr Clin Micro rpt. 2019. July 3. https://doi.org/10.1007/s40588-019-00123-6
Hurwitz SN, Meckes DG Jr. Extracellular Vesicles Distinguish Unique Cancers. Proteomes. 2019. April 11. doi: 10.3390/proteomes7020014. PMID: 30979041
Hurwitz SN, Olcese JM, Meckes DG Jr. Extraction of Extracellular Vesicles from Whole Tissue. J Vis Exp. 2019.
Cheerathodi MR, Meckes DG Jr. The Epstein-Barr virus LMP1 interactome: biological implications and therapeutic targets. Future Virology. 2018 Dec 3. https://doi.org/10.2217/fvl-2018-0120
Sun L, Meckes DG Jr. Methological Approaches to Study Extracellular Vesicle miRNAs in Epstein-Barr Virus-Associated Cancers. Int. J. Mol. Sci. 2018, 19, 2810. https://doi.org/10.3390/ijms19092810
Thery C, Witwer KW,…Meckes DG Jr., et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J. Extracell. Vesicles. 2018 Dec 1. 7:1535750. 10.1080/20013078.2018.1535750 Cited 162 times
Nkosi D, Howell LA, Cheerathrodi M, Hurwitz SN, Tremblay DC, Liu X, Meckes DG Jr. Transmembrane domains mediate intra- and extra-cellular trafficking of Epstein-Barr virus LMP1. J Virol. 2018 Jun 27. pii: JVI.00280-18. doi: 10.1128/JVI.00280-18. [Epub ahead of print]
Hurwitz SN, Sun L, Cole KY, Ford CR, III, Olcese JM, Meckes DG Jr. An optimized method for purification of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease. J Neurosci Methods. 2018 Jun 9. pii: S0165-0270(18)30160-2. doi: 10.1016/j.jneumeth.2018.05.022. [Epub ahead of print]
Hurwitz SN, Cheerathodi MR, Nkosi D, York SB, Meckes DG, Jr. Tetraspanin CD63 bridges autophagic and endosomal processes to regulate exosomal secretion and intracellular signaling of Epstein-Barr virus LMP1. J Virol. 2018 Feb 12;92(5). pii: e01969-17. doi: 10.1128/JVI.01969-17. Print 2018 Mar 1. PubMed PMID: 29212935.
Rider MA, Cheerathodi MR, Hurwitz SN, Nkosi D, Howell LA, Tremblay DC, Liu X, Zhu F, Meckes DG, Jr. The interactome of EBV LMP1 evaluated by proximity-based BioID approach. Virology. 2018 Jan 9;516:55-70. [Epub ahead of print] PubMed PMID: 29329079.Hurwitz, SN, Meckes DG, Jr. 2017. An adaptable polyethylene glycol-based workflow for proteomic analysis of extracellular vesicles. Methods Mol. Biol., 1660:303-317
Hurwitz, S.N., Nkosi D, Conlon MM, York SB, Liu X, Tremblay DC, Meckes DG, Jr. 2017. CD63 regulates Epstein-Barr virus LMP1 exosomal packaging, enhancement of vesicle production, and non-canonical NF-kB signaling. Journal of Virology 91:e02251-16
Hurwitz, SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG, Jr. 2016. Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. Oncotarget. 52:86999
Hurwitz, S.N., M.M. Conlon, M.A. Rider, D.G. Meckes, Jr. 2016. Nanoparticle analysis sheds budding insights into genetic drives of extracellular vesicle biogenesis. J. Extracell. Vesicles. 5:31295.
Rider, M.A., S.N. Hurwitz, D.G. Meckes, Jr. 2016. ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles. Sci. Rep. 6:2397.
Meckes, D.G., Jr. 2015. Exosomal Communication Goes Viral. J Virol. 10:5200-3.
*Listed on JV most read articles for March and April
Meckes, D.G., Jr. 2014. Affinity purification combined with mass spectrometry to identify herpes simplex virus protein-protein interactions. Methods Mol. Biol. 1144:209-22.
Meckes, D.G., Jr., H. P. Gunawardena, R.M. Dekroon, P.R. Heaton, R. Hood Edwards, S. Ozgur, J.D. Griffith, B. Damania, N. Raab-Traub. 2013. Modulation of B-cell exosome proteins by gamma herpesvirus infection. Proc Natl Acad Sci USA. 31:2925-33.
*Special Commentary: Pegtel, D.M., Oncogenic Herpesviruses sending mixed signals. Proc Natl Acad Sci U S A. 31:12503-4
Meckes, D. G., Jr., N.F. Menaker, and N. Raab-Traub. 2013. Epstein-Barr Virus LMP1 Modulates Lipid Raft Microdomains and the Vimentin Cytoskeleton for Signal Transduction and Transformation. J Virol. 3:1201-11.
Meckes, D.G., Jr. and N. Raab-Traub. 2011. Microvesicles and Viral Infection. J Virol. 24:12844-54. Epub 2011
*Listed on JV most read articles for October through April
P.C. Yeh, J. Han, P. Chadha, D.G. Meckes, Jr., M.D. Ward, O.J. Semmes, J.W. Wills. 2011. Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E. J Virol. 18:9425-36.
Han, J., P. Chadha, D.G., Meckes, Jr., N.L. Baird, J.W. Wills. 2011. Interaction and Interdependent Packaging of Tegument Protein UL11 and Glycoprotein E of Herpes Simplex Virus. JVirol. 18:9437-46.
*Kung, C.P., *D.G. Meckes, Jr., and N. Raab-Traub. 2011. EBV Latent Membrane Protein 1 (LMP1) Activates STAT3 and ERK through effects on EGFR and PKCδ. JVirol. 9:4399-408.
*These authors contributed equally to the work.
*Journal of Virology Spotlight Article
Meckes, D.G., Jr., A.R. Marquitz, K.H. Shair, R.H. Edwards, C.P. Kung, and N. Raab-Traub. 2010. A Human Tumor Virus Utilizes Exosomes for Intercellular Communication. Proc Natl Acad Sci U S A. 47:20370-5.
*Cited in: Nature Research Highlights. “Communicators key for cancer virus.” Vol. 468, Page:349. 2010 Nov 18.
*Science Daily, “Cellular Communicators for Cancer Virus Identified.” (Nov 9, 2010); also featured in 10 other science/medical news outlets.
*Priority Paper Evaluation: Middeldorp J.M., D.M. Pegtel. 2011. A human tumor virus extends its reach. Future Virol. 4:413-415.
Meckes, D.G., Jr., J.A. Marsh and J.W. Wills. 2010. Complex Mechanisms for the Packaging of the UL16 Tegument Protein into Herpes Simplex Virus. Virology. 2:208-213.
*Harper, A.L., *D.G. Meckes, Jr., *J.A. Marsh, N.L. Baird, P.C. Yeh, C.B. Wilson, and J.W. Wills. 2009. Interaction Domains of the UL16 and UL21 Tegument Proteins of Herpes Simplex Virus. J Virol. 6:2963-71
*These authors contributed equally to the work.
Meckes, D.G., Jr. and J.W. Wills. 2008. Structural Rearrangement within an Enveloped Virus upon Binding to the Host Cell. J Virol. 21:10429-35.
*Journal of Virology Spotlight Article
*Selected for Faculty of 1000 Biology
Yeh, P.C., D.G. Meckes, Jr., and J.W. Wills. 2008. Analysis of the Interaction between the UL11 and UL16 Tegument Proteins of Herpes Simplex Virus. J Virol. 21:10693-700.
Meckes, D.G., Jr. and J.W. Wills. 2007. Dynamic Interactions of the UL16 Tegument Protein with the Capsid of Herpes Simplex Virus. J Virol. 23:13028-36.
