Welcome to the Tomko Lab!
Diversity and Inclusion
The Tomko lab is committed to maintaining a safe and inclusive (and FUN!) environment for everyone — no ifs, ands, or buts. No matter who we are or where we come from, we are united by science, and we believe that diverse skills, viewpoints, and experiences make us stronger.
Recent News from the Tomko Lab:
July 14th, 2020
A collaborative work with Yanchang Wang's group reporting an unexpected role of Cdc48 in regulating ubiquitin homeostasis with relevance to neurodegenerative disorders was published in Cell Reports. Former Tomko Lab graduate student Lauren Howell was an author. Read it HERE!
May 14th, 2020
The Tomko Lab was awarded a COVID-19 Seed Grant with David Meckes' lab to develop small molecule inhibitors of a key SARS-CoV-2 enzyme. Data from grad students Randi Reed and Jenny Warnock helped to win this award!
May 13th, 2020
Toni Nemec's paper on a system of tagging plasmids for site-specifically modifying yeast proteins with small molecules was published in the journal Yeast. Read it HERE!
March 1st, 2020
The Tomko Lab was awarded a Team Science Grant with Zucai Suo's lab to perform single-molecule studies of proteasome assembly and function. Preliminary data from Toni Nemec helped to win this award!
December 18th, 2019
The Tomko Lab was awarded a grant to study how mutations in an unusually large ubiquitin E3 ligase alters its function to cause vascular malformations and stroke. Data from undergrad Tessa Lochetto helped to win this award!
August 27th, 2019
The second half of Lauren's thesis work was published in Scientific Reports. Read it HERE!
July 11th, 2019
Congratulations to Dr. Lauren Howell, who successfully defended her thesis, entitled "Insights into Proteasome Quality Control: A Mechanistic Analysis of Proteasome Biogenesis and Clearance" today! Lauren is the first Doctor minted from the Tomko lab.
May 5th, 2019
Welcome to undergraduate Jeremy Czerenda, who will be performing research with us over the summer. Jeremy is a rising sophomore IMS major.
March 25, 2019
Graduate student Randi Reed published a paper in Methods in Enzymology describing the use of conformation-selective crosslinking to measure the activation state of the proteasome. Read it HERE!
February 26, 2019
Antonia Nemec's recent paper in Cell Reports was featured on the FSU News Page! Read the write-up HERE!
February 8, 2019
A collaborative work with Hong-Guo Yu's group examining turnover of inner nuclear membrane proteins was published in the Journal of Cell Biology. Read the paper HERE!
January 8th, 2019
The Tomko Lab published a paper in Cell Reports describing how the dedicated proteasomal assembly chaperone, Nas6 (gankyrin oncogene in humans), is released from mature nascent proteasomes. This work raises the exciting possibility that Nas6/gankyrin may scrutinize proteasome intermediates for functionality before licensing them for incorporation into nascent proteasomes, which could potentially be exploited to treat some cancers. Read the paper HERE!
September 25th, 2018
Welcome to Tessa Lochetto, a UROP fellow who will be performing research in the lab during the coming year. Tessa is a sophomore Biology major.
August 30th, 2018
Randi Reed was this year's recipient of the Randolph L. Rill Award for Outstanding Junior Graduate Student. Congrats Randi!
August 27th, 2018
The Tomko Lab's recent paper on the conformational dynamics of the proteasome was the subject of a commentary in Trends In Biochemical Sciences! From the article: "These insights potentially represent a milestone in our understanding of the structural dynamics of the 26S proteasome." Read it HERE!
July 31st, 2018
The Tomko Lab published a paper in collaboration with Eri Sakata's group at Max Planck and Till Rudack at Ruhr University on proteasome conformational dynamics in Cell Reports. This paper provides the first insights into the individual contributions of the six AAA+ family ATPase subunits in controlling the conformational equilibrium of the proteasome. We also reveal the mechanism of gating into the peptidase active sites, which has remained unresolved for over a decade. Congrats to Randi Reed, who is co-first author on this work!
July 16th, 2018
Robb received FSU College of Medicine's "Outstanding Junior Faculty Researcher" Award AND the "Outstanding Junior Faculty Educator Award." Congratulations, Robb!
April 26th, 2018
Jenny Warnock has joined the Tomko lab as a graduate student. Jenny received her Bachelor's degree in chemistry from Clemson University. Welcome aboard Jenny!
March 6th, 2018
Matt Murray has decided to pursue his Ph.D. at Yale University in their Graduate Program in Biological and Biomedical Sciences. Congratulations to Matt!
November 6th, 2017
The Tomko lab published a paper on autophagy of proteasomes in the Journal of Biological Chemistry. This work reveals that nuclear, but not cytoplasmic, proteasomes are disassembled prior to autophagy, and that proteasomes are packaged into small cytoplasmic puncta prior to autophagy in a manner dependent on the conserved sorting nexin Snx4.
June 1st, 2017
Our beloved technician Anna Peterson has set off from the Tomko Lab for graduate school at the University of Connecticut Health Center. Thanks for all of your efforts Anna, you will be missed!
May 5th, 2017
Welcome to Randi Reed, who is joining us as a graduate student! Randi received her Bachelor's degree from the University of Southern Mississippi. Welcome Randi!
February 1st, 2017
The Tomko lab recently published an invited review in Frontiers in Biology and a commentary in Cell Research. Check out our Publications page to read them!
March 1st, 2016
Welcome to Lauren Howell, who is joining us as a graduate student! Lauren received her Bachelor's degree in Biology from the College of Charleston. Welcome Lauren!
September 20th, 2015
Robb's first senior-author manuscript is forthcoming in the October 8th issue of Cell. In this manuscript, we identify a single alpha helix that acts like a key in a lock to remodel the assembling proteasome lid subcomplex. This remodeling exposes the binding site for the remainder of the proteasome. Such assembly-coupled conformational switching is reminiscent of the maturation events observed during viral capsid assembly and may represent a conserved mechanistic theme regulating hierarchical assembly of macromolecular structures.
September 20th, 2015
Welcome to Matthew Murray and Joseph Pelt, who are joining us as UROP students!
July 6th, 2015
Welcome to Anna Peterson, who is joining us as a Laboratory Researcher!
May 1st, 2015
Welcome to Cami Young and Chris Howe, joining us for summer research!
March 10th, 2015
We are officially fully functional! Our FPLC was installed today, which means we can now perform our full complement of techniques in the lab. Robert is especially relieved, as he's been freezing down cell pellets in anticipation of this for weeks! We should be able to start synergizing with the Protein Biology Lab in the CoM's BMS Department as well as with the Institute for Molecular Biophysics now!
February 15th, 2015
Robert was awarded the Florida State University First-Year Assistant Professor Award, which provides salary support for Robert to develop novel but preliminary lines of investigation in his lab.
January 5th, 2015
Antonia A. Nemec will be working with us. She is a talented scientist whose background is in human cancer genetics, and she brings a potent and novel skillset to the lab.
January 5th, 2015
The Tomko lab officially opens at FSU in Room 2310.