Molecular, Cellular, and Developmental Biology
Using a variety of molecular, genetic and imaging tools in diverse model systems such as mammalian cells, yeast, fruit flies, mice, and rats, faculty in this focus area carry out both basic and pre-clinical research aimed at understanding human health and disease. Students gain expertise in the latest microscopy techniques, cell based assays, the use of gene manipulation technologies including CRISPR/Cas9, classic genetic techniques, as well as the latest proteomics, genomics and epigenomics tools. Diseases studied in this focus area include cancer, heart disorders, developmental anomalies, fibrotic disorders, spinal injuries, viral infections, epilepsy, hearing, sleep and neurological disorders.
Faculty Research Interests
- David Meckes Ph.D.
Molecular pathogenesis of Epstein-Barr Virus-associated cancers.
- Timothy Megraw Ph.D.
The functions of centrosomes and cilia in cell division, development and disease.
- Jose R Pinto Ph.D.
Cardiac and skeletal muscle regulation and inherited diseases. Molecular basis of striated muscle contraction.
- Yi Ren Ph.D.
Macrophage function in cancer and CNS disease
- Gregg Stanwood Ph.D.
The developmental basis of mental health disorders.
- Branko Stefanovic Ph.D.
Molecular mechanisms of liver fibrosis.
- Zucai Suo. Ph.D.
Multi-disciplinary research in DNA replication and damage repair, gene editing, and drug discovery.
- Robert J Tomko Jr. Ph.D.
Multidisciplinary analyses of biomedically important molecular machines; ubiquitin signaling; drug discovery.
- Yanchang Wang Ph.D.
Chromosome segregation regulation and the response to the expression of misfolded protein.
- Yuan Wang Ph.D.
Development and plasticity of neuronal circuits and their pathology in neurodevelopmental disorders and neurodegeneration.
- Yue Julia Wang Ph.D.
Single-cell transcriptomic profiling of pancreatic endocrine cells in normal, diabetes, and other metabolic disorders.