IPRD funded research by Yi Zhou
Brain organoids: The goal of our project is to engineer brain organoids from healthy individuals and pediatric rare disease patients. The source of the organoids will be human induced pluripotent stem cells. Single cell RNA sequencing technology will be used to identify different cell types and cellular and molecular signaling pathways to understand disruptions in cellular processes associated with the disease progression. Identifying the pathway disruptions can become a new platform for identification of drug targets for pediatric rare diseases.
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