The last word in DNA replication, recombination, and repair: fidelity of DNA ligases
Start Date
Wed, 2/15/2023
Start Time
12:00 pm
End Date
Wed, 2/15/2023
Location
Durell Peaden Auditorium
Area
Central Campus
State
Florida
Event Type
Seminar
Audience
Adults
Biomedical Graduate Students
Campus Faculty
Campus Staff
Students
Presenter
Pat O'Brien
Event Host
Zucai Suo
Event Sponsor
Biomedical Sciences
Description
DNA ligases maintain genomic integrity by finding and catalyzing the joining of single and double-stranded breaks. Humans have three DNA ligase genes that differ in their biochemical activities. All DNA replication and recombination and almost all DNA repair pathways create nicked DNA intermediates, and therefore DNA ligases play a critical role in DNA metabolism. I will discuss recent progress in understanding the structural and mechanistic underpinnings for the fidelity of DNA ligases I and III. The results have implications for understanding genetic deficiencies in each ligase, and in targeting cancers with altered expression of DNA ligases.
Contact Name
Tiffany McNabb
Contact Email
Contact Phone
Add Event to Calendar
Wed, 2/15/2023 12:00 pm
Wed, 2/15/2023
Eastern
The last word in DNA replication, recombination, and repair: fidelity of DNA ligases
Durell Peaden Auditorium
Durell Peaden Auditorium