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Yi Zhou Ph.D.

Yi Zhou Ph.D.

Associate Professor
Main Campus

Job Description

Dr. Zhou is a scientist who is conducting his research in the area of molecular and cellular neurosciences. He also teaches medical students in basic sciences in small group sessions.


Dr. Zhou comes to the FSU College of Medicine from the College of Medicine, University of Alabama at Birmingham, where he was an assistant professor from 2003 to 2007. He obtained his Ph.D. from University of Minnesota, and carried out postdoctoral research at Brandeis University.


1995 Doctor of Philosophy, University Of Minnesota Twin C. Major: Biological Sciences.

1987 M.S. Physiology, Peking University: China. Major: Physiology.

1984 B.S. Biology, Peking University: China. Major: Biology.

Postdegree Education and Training

1995–1999 Post Doctoral training in Neurosicences, Brandeis University, Waltham, MA.


FSU University Service

Member, FSU Neuroscience Program Executive Committee (2009–present).

Voting member, FSU ACUC Committee (2009–present).

FSU Department Service

Member, Space Committee (2010–present).

Member, Faculty Search Committee (2009–2010).

Member, Graduate Admission Committee (2008–2009).

Member, Faculty Development Committee (2008–2009).

FSU Program Service

Member, FSU Neuroscience Program Executive Committee (2010–present).

The Profession

Editor for Refereed Journals

Global Journal of Biotechnology, Senior Editor (2010–present).

Editorial Board Membership(s)

International Journal of Biochemistry and Molecular Biology (2011–present).

Guest Reviewer for Refereed Journals

Molecular and Cellular Neurosciences (2008–present).

Journal of Cell Science (2007–present).

Cell Proliferation (2007–present).

PNAS (2006–present).

Neuropharmacology (2005–present).

Reviewer or Panelist for Grant Applications

National Science Foundation (2006–present).

National Institutes of Health (2004–present).


Sept. 2007 -Aug. 2012 (1R01NS050355-01)
Functions of the N-Type Ca Channel/14-3-3 Interaction

Aug. 2006 - July 2010 (0635497N)
American Heart Association
Regulation of Neurotransmissions in Sympathetic Neurons: Function of the 14-3-3/Ca Channel Interaction

2005 FRET Microscopy Workshop award
Cell Adhesion and Matrix Research Center, UAB

1995 Lifson/Johnson Memorial Award
Minnesota Medical Foundation

1994 Allan Hemingway Endowed Scholarship
Minnesota Medical Foundation

1994 Doctoral Dissertation Special Grant,
Graduate School, University of Minnesota


Society for Neuroscience.
American Association for Advancement of Science.

Research Focus

Molecular and Cellular Basis of Neurodegenerative Diseases
Animal Models of Neuropsychiatric Disease
Functions and Regulation of Neuronal Ion Channels


Foote M, Qiao H, Graham K, Wu Y, Zhou Y. (2015) Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice. Biological Psychiatry (In press)

Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, Feng L, Hou Z, Zhou A, Zhou Y, Li Y. (2015) 14-3-3t Promotes Surface Expression of Cav2.2 (a1B) Ca2+ Channels. J Biol Chem. 290(5):2689-98.

Qiao H, Foote M, Graham K, Wu Y, Zhou Y. (2014) 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory. J Neurosci. 34(14):4801-8.

Jia B, Wu Y, Zhou Y. (2014) 14-3-3 and aggresome formation: implications in neurodegenerative diseases. Prion. Mar-Apr;8(2).

Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y. (2013) 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes. J Cell Sci. 126(Pt 18):4173-86.

Sun C, Qiao H, Zhou Q, Wang Y, Wu Y, Zhou Y., Li Y. (2013) Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins. J Biol Chem. 288(34):24676-90.

Zhou Y, Zhao M, Fields GB, Wu CF, Branton WD. (2013) d/?-Plectoxin-Pt1a: an excitatory spider toxin with actions on both Ca(2+) and Na(+) channels. PLoS One. 8(5):e64324.

Gao X, Qiao Y, Jia B, Jing X, Cheng B, Wen L, Tan Q, Zhou Y, Zhu B, Qiao H. (2012) NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36. Evid Based Complement Alternat Med. 2012:438460.

Foote M, Zhou Y. (2012) 14-3-3 proteins in neurological disorders. Int J Biochem Mol Biol. 3(2):152-64.

Huang, Z., Xu, Z., Wu, Y., & Zhou, Y. (2011). Determining nuclear localization of alpha-synuclein in mouse brains. Neuroscience, 199, 318-332.

Li, Y., Liu, X., Wu, Y., Xu, Z., Li, H., Griffith, L., & Zhou, Y. (2011). Intracellular regions of the eag potassium channel play a critical role in generation of voltage-dependent currents. Journal of Biological Chemistry, 286(2), 1389-99.

Liu, X., Wu, Y., & Zhou, Y. (2010). Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel. Channels, 4(4), 311-318.

Lu, R., Li, Y., Zhang, Y., Chen, Y., Shields, A. D., Winder, D. G., Angelotti, T., Jiao, K., Limbird, L. E., Zhou, Y., & Wang, Q. (2009). Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is due to ligand-selective internalization. Journal of Biological Chemistry, 284(19), 13233-43. *co-first authors.

Qiao, L., Hamamichi, S., Caldwell, K. A., Caldwell, G. A., Yacoubian, T. A., Wilson, S., Xie, Zuo-Lei, Speake, L. D., Parks, R., Crabtree, D., Liang, Q., Crimmins, S., Schneider, L., Uchiyama, Y., Iwatsubo, T., Zhou, Y., Peng, L., Lu, Y., Standaert, D. G., Walls, K. C., Shacka, J. J., Roth, K. A., & Zhang, J. (2008). Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Molecular Brain, 1(17), 17-35. doi:10.1186/1756-6606-1-17

Li ,Y., Wu, Y. Li, R. and Zhou, Y. The Role of 14-3-3 Dimerization in its Modulationof the Cav2.2 channel. (2007) Channels 1:1, e1-e2.

Li ,Y., Wu, Y. and Zhou, Y. Modulation of Inactivation Properties of Cav2.2 Channels by 14-3-3 Proteins. (2006) Neuron 51:755–771.

Lai, M., Wang, F., Rohan, J.G., Maeno-Hikichi, Y., Chen, Y., Zhou, Y., Gao, G., Sather,W.A., Zhang, J.F. (2005) A tctex1-Ca(2+) channel complex for selective surface expression of Ca(2+) channels in neurons. Nat Neurosci., 8:435-442.

Zhou, Y., Reddy, S., Murrey, H., Fei, H. and Levitan, I.B. (2003) Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calciumdependent potassium channel. J. Biol. Chem., 278: 10073-80.

Zhou, Y., Fei, H. and Levitan, I.B. (2003) An interaction domain in slob necessary for its binding to the slowpoke calcium-dependent potassium channel. Neuropharmacology 45(6): 714-719.

Zhou, Y., Wang, J., Wen, H., Kucherovsky, O., Levitan, I.B. (2002) Modulation of Drosophila slowpoke calcium-dependent potassium channel activity by bound protein kinase A catalytic subunit. J. Neurosci., 22: 3855-3863.

Zhou, Y., Schopperle, W.M., Murrey, H., Jaramillo, A., Dagan, D., Griffith, L.C. and Levitan, I.B. (1999) A Dynamically Regulated 14-3-3, Slob, and Slowpoke Potassium Channel Complex in Drosophila Presynaptic Nerve Terminals. Neuron 22:809-818.