Yang Hou, Ph.D., and her research team have co-authored a study titled “Internalizing and Externalizing Symptoms in Individuals with Neurofibromatosis Type 1: A Systematic Review and Meta-Analysis,” published in Springer Nature.

This study provides a comprehensive review and meta-analysis of the psychosocial challenges faced by individuals with neurofibromatosis type 1 (NF1), specifically focusing on internalizing and externalizing symptoms, areas that have been underexplored but have a significant impact on quality of life. The research reveals that individuals with NF1 experience higher levels of depression, anxiety, somatic symptoms, and aggression compared to unaffected individuals. Notably, these disparities were more pronounced in studies involving participants with ADHD or lower verbal IQ. The findings underscore the critical need for early identification and intervention to address these symptoms in individuals with NF1. Future research should aim to identify key predictors that can guide effective interventions and deepen our understanding of these psychosocial challenges.