Building a proteasome: unraveling the secrets of how nature assembles macromolecules

seminar flyer
Start Date
Wed, 4/05/2023
Start Time
12:00pm
End Date
Wed, 4/05/2023
Location
COM 11400
Area
Central Campus
State
Florida
Event Type
Seminar
Audience
Adults
Biomedical Graduate Students
Campus Faculty
Presenter
Daniel Betancourt
Event Host
Robert Tomko
Event Sponsor
Biomedical Sciences
Description

The 26S proteasome is a large macromolecular complex responsible for the vast majority of regulated protein degradation in humans and other eukaryotes. Disruption to proteasomal proteolysis causes or exacerbates numerous human diseases. Assembly of this critical molecular machine from its 66 individual subunits with high efficiency and fidelity presents a substantial challenge which organisms must overcome. Our current understanding of proteasome biogenesis is derived by static snapshots of incomplete subunit complexes, assumed to be assembly intermediates. However, the link between these complexes and assembly pathways is tenuous and incomplete and has led to competing models being proposed. Furthermore, available models provide rigid pathways which are insufficient for complex situations including increased proteolytic demand during times of stress. Here we present a data-rich, dynamic approach to unraveling the mechanisms for poroteasomal biogeneis with implications for macromolecular assembly at large.

Contact Name
Tiffany McNabb

Add Event to Calendar Wed, 4/05/2023 12:00pm Wed, 4/05/2023 Eastern Building a proteasome: unraveling the secrets of how nature assembles macromolecules
COM 11400