Seminar Series: ADP-ribosyltransferases and the innate immune system

headshot of Professor Luscher
Start Date
Wed, 3/08/2023
Start Time
12:00 pm
End Date
Wed, 3/08/2023
End Time
1:00 pm
COM 1400 & Zoom
Central Campus
Event Type
Biomedical Graduate Students
Campus Faculty
Campus Staff
Prof. Dr. Bernhard Lüscher
Event Host
Julia Wang
Event Sponsor
Biomedical Sciences

I will discuss the new developments that suggest a role of ADP-ribosyltransferases (ARTs) as components of the innate immune system. This senses pathogen-associated molecular patterns (PAMPs), which triggers the synthesis of interferons (IFNs). In turn the expression of IFN-stimulated genes (ISGs) is induced, allowing the host to react swiftly to viral infections. ISGs include several genes encoding ARTs, enzymes that catalyze ADP-ribosylation of proteins and nucleic acids using NAD+ as cofactor. Emerging evidence demonstrates that some mono-ARTs function as PAMP receptors and modify both host and viral proteins relevant for viral replication. Support for mono-ADP-ribosylation in virus-host interaction stems from the findings that some viruses, including Chikungunyavirus (CHIKV), encode mono-ADP-ribosylhydrolases, which antagonize cellular mono-ARTs. PARP10, the first identified cellular mono-ART, modifies and inhibits the protease function of CHIKV. This prevents poly-protein processing and viral replication. The viral non-structural protein 3, which encodes a mono-ADP-ribosylhydrolase, antagonizes cellular mono-ADP-ribosylation and reactivates the protease. This provides mechanistic information for the essential function of this enzymatic activity for CHIKV replication.

Contact Name
Tiffany McNabb
Contact Email
Contact Phone
Summary of the functions of mammalian ADP-ribosyltransferase family members

Add Event to Calendar Wed, 3/08/2023 12:00 pm Wed, 3/08/2023 1:00 pm Eastern Seminar Series: ADP-ribosyltransferases and the innate immune system
COM 1400 & Zoom