BMS Seminar Series: The Molecular Underpinnings of Diastolic Dysfunction

Seminar series flyer containing details included on this event listing.
Start Date
Wed, 5/17/2023
Start Time
12:00 PM
End Date
Wed, 5/17/2023
Durrell Peaden Auditorium and Zoom
Event Type
Biomedical Graduate Students
Campus Faculty
Dr. Matthew A. Caporizzo
Event Host
Paula Nieto-Morales and Dr. Jose Pinto
Event Sponsor
Biomedical Sciences

Heart disease remains the leading cause of death and disability in developing countries and is on the rise.  A common feature of heart disease is diastolic dysfunction, an inability of the heart to fill with blood, caused by impaired relaxation and stiffening of the heart muscle.  To date, there are no therapies that directly improve diastolic function which stems from limited therapeutic targets and poor techniques to characterize diastole in the laboratory.  In a rat model of diastolic heart disease, we have identified that microtubule stabilization contributes to cardiomyocyte stiffness and impaired relaxation.  To determine how microtubule destabilization impacts diastolic dysfunction in working myocardium, we have developed a working cardiac slice technique that mimics diastolic physiology.  With this we demonstrate that microtubule depolymerization is sufficient to improve relaxation and increase contractility.

Contact Name
Tiffany McNabb
Contact Phone

Add Event to Calendar Wed, 5/17/2023 12:00 PM Wed, 5/17/2023 Eastern BMS Seminar Series: The Molecular Underpinnings of Diastolic Dysfunction
Durrell Peaden Auditorium and Zoom