Several faculty members in the College of Medicine Department of Biomedical Sciences have authored noteworthy studies in 2019. Among them, Professor Yi Ren published a study in Nature Neuroscience shedding light on new developments in understanding spinal cord injuries. Her work was featured on FSU Headlines
Other recent noteworthy articles published by researchers in the Department of Biomedical Sciences include:
Jan. 1, 2019
Lead author and PI Sanjay Kumar, Ph.D., post-doctoral associate Stephen Beesley, graduate student Thomas Sullenberger and colleagues published “Colocalization of distinct NMDA receptor subtypes at excitatory synapses in the entorhinal cortex” in the Journal of Neurophysiology (Vol. 121, Issue 1). The article is in the first percentile (1%) among nearly 13 million research publications tracked by Altmetric for the quality and quantity of online attention it has received (as of Jan. 11, 2019). Link to published article
Jan. 8, 2019
Robert J. Tomko Jr., Ph.D., authored “An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes” in the online, open-access journal Cell Reports. The study answers a long-standing question regarding how the proteasome is assembled from more than 66 individual protein "parts" and revealed a potential strategy to treat a subset of cancers. Link to published article
Jan. 23, 2019
Branko Stefanovic, Ph.D., was first author for “Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound" in the open-access journal Scientific Reports. The study highlights a promising compound that dramatically reduced production of Type I collagen during experimental screening. Type I collagen causes fibrosis – the excessive scarring of internal organs. The most common form is liver fibrosis, a deadly disease for which there presently is no cure. Link to published article
Feb. 1, 2019
Richard Nowakowski, Ph.D., and coauthors Joseph Bundy, Ph.D., and Cynthia Vied, Ph.D., published “Sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer’s disease: a multi-omic analysis” in the Journal of Comparative Neurology (Volume 527, Issue 2). The study found early molecular changes representing potential biomarkers for disease development that could become candidates for pharmacological intervention. The study also reaffirms the importance of studying subjects of each sex in animal models to respect differences in molecular pathological mechanisms. Link to published article