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Michael Blaber Ph.D.

Michael Blaber Ph.D.

Main Campus

Job Description

Research, Teaching and Service


Dr. Blaber graduated with a B.A. in Biochemistry/Molecular Biology from the University of California at Santa Barbara in 1980. At the time, molecular biology was a new field, and UCSB was one of the few institutions that offered an undergraduate degree program in this area. After graduation, Blaber was recruited by Genentech Inc. to work as a research assistant in their Protein Chemistry group. Genentech was one of the first biotech startup companies, and Blaber was the 120th employee. After five exciting years studying the properties of recombinant human plaminogen activators, Blaber left Genentech and entered the Ph.D. program in the Department of Biological Sciences in the College of Medicine at UC Irvine (in the laboratory of Dr. Ralph A. Bradshaw). During this time Blaber studied structure/function relationships of murine glandular kallikreins, and was supported by an undergraduate NIH fellowship and an Earl C. Anthony dissertation fellowship. After graduating, Blaber was a Postdoctoral Fellow in the laboratory of Dr. Brian Matthews, Howard Hughes Medical Institute, University of Oregon. During this time, Blaber was supported by an NIH Postdoctoral Fellowship to study the structure and stability relationships of T4 lysozyme mutants. After completing his Postdoctoral work, Blaber joined the Department of Chemistry at FSU as an assistant professor, receiving a University Teaching Award in 1999. Blaber earned tenure, and promotion to associate professor in 2000. In fall 2005 Blaber joined the Department of Biomedical Sciences in the College of Medicine at FSU. In 2007 Blaber was promoted to Professor and also received the Outstanding Senior Faculty Researcher Award. In 2009 Blaber received the E.K. Frey/E. Werle Gold Medal for research in the area of Kallikrein-related peptidases. In 2009-2010 a total of five patents were issued related to work on Fibroblast Growth Factor-1 mutants from the Blaber lab.


1976-1980 BA Biochemistry/Molecular Biology, University of California at Santa Barbara
1985-1990 Ph.D. Biological Chemistry, University of California at Irvine


Editorial Board:
Editorial Board, Archives of Biochemistry & Biophysics (2010-2013)
Editorial Board, Research and Reports in Biology (2010-2013)
Editorial Advisory Board, Protein Science (2003-2009)
Editorial Board, Molecular and Cellular Proteomics (2001-2007)

Peer Review:
National Science Foundation, Integrative Organismal Biology Panel Ad hoc (8/05)
National Science Foundation, Molecular Biochemistry Panel (10/04 - 10/07)
American Heart Association, Cell Function & Metabolism (10/04 - 10/05)


E.K. Frey/E. Werle Gold Medal, FSU 2009
Outstanding Senior Faculty Researcher Award, Department of Biomedical Sciences, FSU (2007)
Faculty Ranking #1, Department of Chemistry & Biochemistry, FSU (2002)
University Teaching Award, FSU (1999)
First Year Assistant Professor Award, FSU (1995)
N.I.H. Postdoctoral Fellowship GM13709-01, Institute of Molecular Biology, University of Oregon, Eugene OR (3/90-2/93)
N.I.H. Predoctoral Fellowship GM07134-11, University of California, Irvine CA (9/86-8/89)
Earl C. Anthony Dissertation Fellowship, University of California, Irvine CA (9/89-12/89)

U.S. Patent 7,790,682, Engineered Human Acidic Fibroblast Growth Factors and Associated Methods, Blaber, M. and Brych, S. (9/10)
U.S. Patent 7,776,825, Mutant Polypeptides of Fibroblast Growth Factor 1, Blaber, M. and Dubey, V.K. (8/10)
U.S. Patent 7,754,216 B2, Method of Treating Multiple Sclerosis with Anti-K6 Antibody, Scarisbrick, I.A., Blaber, S.I., Blaber, M. and Rodriguez, M. (7/10)
U.S. Patent 7,696,171, Mutant Polypeptides of Fibroblast Growth Factor 1, Blaber, M. and Dubey, V.K. (4/10)
U.S. Patent 7,659,379, Mutants of Human Fibroblast Growth Factor Having Increased Stability and/or Mitogenic Potency, Blaber, M. and Dubey, V.K. (2/10)
U.S. Patent 7,595,296, Mutant Polypeptides of Fibroblast Growth Factor 1, Blaber, M. and Dubey, V.K. (9/09)
European Patent 1,513,553 B1, Methods and Materials for Treating and Diagnosing Kallikrein-6 Related Inflammatory Conditions, Scarisbrick, I.A., Blaber, S.I. and Blaber, M. (11/08)


American Chemical Society, Biophysical Society, Protein Society, American Association for the Advancement of Science (AAAS), Federation of American Societies for Experimental Biology (FASEB), International Union of Crystallographers (IUCr), American Society for Biochemistry & Molecular Biology (ASBMB)

Research Focus

Protein structure, stability and folding; Mutational study of human fibroblast growth factor 1 for angiogenic therapy; Structural biology and enzymology of human kallikrein-related peptidases; Role of human kallikrein-related peptidase 6 in human disease.


Regulatory role of Kallikrein 6 in Lymphocyte Survival, Scarisbrick, I.A., Epstein, B., Cloud, B., Yoon, H., Wu, J., Blaber, S.I., Blaber, M., Vandell, A.G. and Bryson, A. PLoS ONE 6(3): e18376. doi:10.1371/journal.pone.0018376

A polypeptide "building block" for the ß-trefoil fold identified by "top-down symmetric deconstruction", Lee, J., Blaber, S., Dubey, V. and Blaber, M., J. Mol. Biol. 407, 744–763 (selected by Faculty of 1000; Cover Article)

Experimental support for the evolution of symmetric protein architecture from a simple peptide motif, Lee, J. and Blaber, M., Proc. Natl. Acad. Sci. 108, 126-130 (2011) (selected by Faculty of 1000)

Increased Functional Half-life of Fibroblast Growth Factor-1 by Recovering a Vestigial Disulfide Bond, Lee, J. and Blaber, M., J. Proteins Proteomics, 1, 37-42 (2010)

Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans., Andrade, D., Assis, D.M., Lima, A.R., Oliveira, J.R., Araujo, M.S., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., Arch. Biochem. Biophys. 498, 74-82 (2010)

Functional intersection of the Kallikrein-related peptidases (KLKs) and thrombostasis axis, Blaber, M., Yoon, H., Juliano, M.A., Scarisbrick, I.A., and Blaber, S.I., Biological Chemistry 391, 311-320 (2010)

Analysis of the Dynamics of Assembly and Structural Impact for a Histidine Tagged FGF-1 – 1.5 nm Au Nanoparticle Bioconjugate, Kogot, J.M., Parker, A.M., Lee, J., Blaber, M., Strouse, G.F. and Logan, T.M., Bioconjugate Chemistry 20, 2106–2113 (2009)

X-ray Structure and Biophysical Properties of Rabbit Fibroblast Growth Factor-1, Lee, J., Blaber, S.I., Irsigler, A., Aspinwall, E. and Blaber, M., Acta Cryst. F. 65, 1097-1104 (2009)

Structural Basis of Conserved Cysteine in the Fibroblast Growth Factor Family: Evidence for a Vestigial Half-cystine, Lee, J. and Blaber, M., J. Mol. Biol. 393, 128-139 (2009)

The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-life of Fibroblast Growth Factor-1, Lee, J. and Blaber, M., J. Mol. Biol. 393, 113-127 (2009)

A Completed KLK Activome Profile: Investigation of Activation Profiles of KLK9, 10 and 15, Yoon, H., Blaber, S.I., Debela, M., Goettig, P., Scarisbrick, I.A. and Blaber, M., Biological Chemistry 390, 373-377 (2009)