Dr. Lee is an associate professor who is engaged in research in the moloecular basis for circadian rhythms.
Dr. Lee obtained a B.S. from Seoul National University in South Korea. He attended Rutgers University, where he obtained his Ph.D. in microbiology and molecular genetics in 1999.
2000–2003 postdoctoral fellow, UMass Medical School.
1993–1998 Doctoral Degree, Department of Microbiology and Molecular Genetics, Rutgers University.
FSU University Service
Member, FSU Animal Care and Use Committee (2007–2009).
Member, FSU Biosafety Committee (2006–present).
FSU Department Service
Member, Core facility committee (2009–present).
Member, Faculty search committee (2006–2009).
Member, By-Laws and Policy Committee (2006).
Reviewer or Panelist for Grant Applications
American Heart Association Grants (2009–present).
The German Isreal Foundation (GIF) (2009–present).
NIH F31/32 Grants (2006–present).
Ohio Cancer Research Associates (2005–present).
Invited Speaker, International Symposium for Time Studies in Japan (2010).
Invited Speaker, University of Florida (2010).
Outstanding Junior Faculty Researcher, College of Medicine, Florida State University (2009).
Invited Speaker, Scripps Research Institute, Jupiter, FL (2005).
Society for Biological Rhythms and Sleep
Society for Neuroscience
The major objective of my research is to understand the molecular basis for our circadian (daily) rhythms. Circadian rhythms have been observed in nearly all organisms from cyanobacteria to humans. These rhythms are under the direct influence of environmental cues, most notably the day/night cycle, and by a genetically determined, endogenous clock called the “circadian clock.” The most familiar circadian rhythm is our own sleep/wake rhythm. However, there is circadian rhythmicity in many aspects of physiology, including alertness, activity, hormone production and drug efficacy. These and other daily activities and physiological processes are under the control of the circadian clock. The circadian clock is cell-autonomous and ubiquitously present in most tissues.
To understand the molecular mechanism of our circadian rhythms, my lab is using the mouse as a model system. Currently, we are employing biochemical and genetic techniques to discover novel clock genes and to understand the mammalian circadian clock at a molecular level. The discovery of new clock components and regulatory pathways will not only broaden our understanding of circadian physiology but also provide additional molecular handles for manipulating the clock for the treatment of human circadian disorders.
Lee, C. (2011). Stoichiometric interaction among clock proteins regulates robustness of circadian rhythms. JBC, 286, 7033-42.
Lee, H., Chen, R., Etchegaray, J. P., Weaver, D. R., & Lee, C. (2011). The balance between CK1 and PP1 regulates PER phosphorylation and circadian oscillator speed. PNAS, 108, 16451-6.
Lee, C., Chen, R., & Lee, Hyeong-min. (2010). PERpetual motion of the circadian negative feedback loop. Cell Cycle, 9(5), 853-854.
Ansari, N., Agathagelidis, M., Lee, C., Korf, Horst-Werner, & von Gall, C. (2009). Differential maturation of circadian rhythms in clock gene proteins in the suprachiasmatic nucleus and the pars tuberalis during mouse ontogeny. European Journal of Neuroscience, 29(3), 477-489.
Lee, H., Chen, R., Lee, Y., Yoo, S. and Lee, C. Essential roles of CKI? and CKI? in the mammalian circadian clock. (2009) Proceedings of the National Academy of Sciences(PNAS) 106: 21359-64
Chen, R., Schirmer, A., Lee, Y., Lee, H., Kumar, V., Yoo, S., Takahashi, J.S. and Lee, C. (2009) Rhythmic mPER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Molecular Cell 36: 417-430
Ramsey, K.M., Yoshino, J., Brace, C.S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H., Chong, J.L., Buhr, E.D., Lee, C., Takahashi, J.S. and Imai, S., Bass, J. (2009) Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis. Science 324:651.
Ansari, N., Agathagelidis, M., Lee, C., Korf, H. and von Gall, C. (2009) Differential maturation of circadian rhythms in clock gene proteins in the suprachiasmatic nucleus and the pars tuberalis during mouse ontogeny. European Journal of Neuroscience. 29:477-89
Chen, R., Seo, D., Bell, E., von Gall, C. and Lee, C. (2008) Strong resetting of the mammalian clock by constant light followed by constant darkness. Journal of Neuroscience. 28:1839-47
Antoch, M.P., Gorbacheva, V.Y., Vykhovanets, O., Toshkov, I.A., Kondratov, R.V., Kondratova, A.A., Lee, C. and Nikitin, A.Y. (2008) Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 7:1197-204.
Siepka, S. M., Yoo, S., Park, J., Lee, C. and Takahashi, J.S. (2007) Genetics and Neurobiology of Circadian Clocks in Mammals. Cold Spring Harbor Symposia on Quantitative Biology 72:251-9.
Busino L, Bassermann F, Maiolica A, Lee C, Nolan P.M., Godinho S, Draetta G.F. and Pagano., M. (2007) SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins. Science 316:900-4.
Siepka S.M., Yoo S, Park J, Song W, Kumar V, Hu Y, Lee C and Takahashi J.S. (2007) Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression. Cell 129:1011-23.
Kondratov RV, Kondratova AA, Lee C, Gorbacheva VY, Chernov MV, Antoch MP. (2006) Post-Translational Regulation of Circadian Transcriptional CLOCK(NPAS2)/BMAL1 Complex by CRYPTOCHROMES. Cell Cycle 5: 890-5.
Yoo, S.H., Ko, C., Lowrey, P., Buhr, E., Song, E.J., Chang, S., Yoo, O.J., Yamazaki, S., Lee, C. and Takahashi, J.S. (2005) A novel E-box Enhancer Drives Mouse Period2 Circadian Oscillations in vivo. PNAS 102: 2608-2613
Lee, C., Weaver, D.R., and Reppert, S.M. (2004) Direct association between mouse PERIOD and CKI? is critical for a functioning circadian clock. Molecular and Cellular Biology.24: 584-594