Dr. Hurt has been involved in medical education for more than 25 years, first at the University of Tennessee and later at the Baylor College of Medicine. She came to FSU in 1987 and joined the team of professors teaching biochemistry to medical students in the Program in Medical Sciences (PIMS). In 1992, Dr. Hurt became the Director of PIMS, working closely with the University of Florida College of Medicine to assure the quality of the first-year medical education program at FSU. In 1992, Dr. Hurt joined the faculty of the department of biological science, where she earned tenure. She taught microbiology to undergraduates, advanced molecular biology to graduate students, and taught an Honors Seminar in the FSU Honors Program. She served as acting dean of the new College of Medicine from 2000 to 2001. She was associate dean for student affairs, admissions and outreach from 2001-2004 and assumed the role of associate dean for research and graduate programs in 2004. She was named senior associate dean for research and graduate programs in 2009. She is the founding faculty member of the College of Medicine, and leads a molecular biology research group engaged in dissecting the regulation of cellular division at the molecular level through the phosphorylation of YY1. She enjoys working with students in the laboratory and has directed the research of nine students who earned their Ph.D. degree, two who earned an M.S., 2 more students currently working toward their degrees and over 30 undergraduate researchers at FSU since 1992.
B.S., Biology, Henderson State University, Arkadelphia, Ark.
Ph.D., Microbiology, University of Tennessee Center for the Health Sciences, Memphis, Tenn.
Postdoctoral, Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas
Grant Reviewer, National Science Foundation, EPSCOR, Biochemical Genetics, and Israel Science Foundation
Journal Reviewer, Genome, Molecular Biology Reports, Nucleic Acids Research, Gene, Journal of Cellular Biochemistry, Proceedings of the National Academy of Sciences, and Academic Medicine.
Research Committee, State of Florida Biomedical Research Advisory Committee, 2006-2012
FSU Council on Research and Creativity, 2004-present; Chair, 2010-present.
Medical Student Admissions:
University of Florida College of Medicine, 1991-1993
FSU Program in Medical Sciences, 1989-2000; FSU College of Medicine, 2000-2005.
Curriculum Committee Service:
University of Florida College of Medicine, 1992-2000, Biochemistry Subcommittee, 1993-1995
FSU Dept. of Biological Science, 1991-2000
FSU PIMS, 1991-2001; FSU College of Medicine, 2000-2004.
FSU PIMS LCME Working Group, Chair, 1992-1993
PIMS LCME Accreditation Task Force, 1998-2000
College of Medicine Accreditation Task Force, 2000-2005; 2008-2010
FSU Faculty Searches:
PIMS, 1993, Chair-1994, 1999,2000; Biological Science, 1996, Chair Search 1997
College of Engineering, Biomedical Engineering, 2000
College of Social Sciences Epidemiologist Search, 2001
College of Medicine Dean Search, Chair, 2000-2001, COM Faculty Search, 2000-2002
Biomedical Sciences Faculty Search, 2002-2006
Biomedical Sciences Chair, 2009-2010
Medical Humanitites and Social Sciences Chair Search, 2009-2010
Faculty Peer Evaluation:
FSU Dept. of Biological Science Faculty Evaluation Committee, 1994-1995
Teaching Incentive Program Award Committee, 1995
Junior Faculty Mentorship Committees 1997-2001
COM Biomedical Sciences Faculty Reviews, 2003, 2004
COM Tenure and Promotion Committee, 2001-present
FSU Tenure and Promotion Committee, 2004-present.
FSU PIMS Suite, Duxbury Hall, Chair, 1992-1993
FSU College of Medicine Transitional Space Renovation Committee, 2001-2002
FSU College of Medicine Building Committee, Chair, 2001-2006
NIH Medical Genetics Trainee, Departments of Medicine, Pediatrics and Cell Biology, Baylor College of Medicine, Houston, Texas, 1978-1981
Robert A. Welch Fellow, Department of Cell Biology, Baylor College of Medicine, Houston, Texas
Visiting Professorships for Women Award, National Science Foundation, 1987-1989
Kappa Delta Sorority Excellence in Teaching Award, Florida State University, 1993
Florida Teaching Incentive Award, Florida State University, 1996
Harvard Macy Institute Leaders in Medical Education, 1999
Honors Program Teaching Excellence Recognition, Florida State University, 2000
Visiting Professor, Harvard Macy Institute, Harvard Medical School, 2003-present
Molecular Biology of the Cell Paper of the Year Award: Whitfield, M.L., Sherlock, G., Salanha, A., Murray, J., Ball, C., Alexander, K., Matese, J., Perou, C., Hurt, M., Brown, P., and Botstein, D. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell.13:1977-2000, 2003
Jim King Leadership Award for the State of Florida, 2011.
FL CURED Jim King Leadership Award for the State of Florida, 2011.
American Medical Women’s Association, Woman in Science Award, 2015
Member, American Association for the Advancement of Science, 1987-present
Member, American Society for Microbiology, 1992-present
Member, American Society for Biochemistry and Molecular Biology, 2002-present
Dr. Hurt studies the regulation of mammalian gene expression, specifically those events controlling transcription initiation in general and in the cell division cycle in particular. Her laboratory is examining the cellular signals that control cell growth and proliferation. These cellular events occur at the point of the cell cycle where the cell makes initial decisions leading to proliferation or nonproliferation, contributing to the understanding of the molecular basis of cancer. A current focus is the pattern of post-translational modifications of the transcription factor YY1 in the cell cycle and effects on YY1 function. The current focus of research in the lab is post translations modifications, primarily phosphorylation, of the transcription factor YY1 in the cell cycle and effects of these modification on YY1 function.
Rizkallah R, Batsomboon P, Dudley GB, Hurt MM.Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins. Oncotarget. 2015 Jan 30;6(3):1446-61.
Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y.14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes .J Cell Sci. 2013 Sep 15;126(Pt 18):4173-86. doi: 10.1242/jcs.126102.
Richmond D, Rizkallah R, Liang F, Hurt MM, Wang Y. Slk19 clusters kinetochores and facilitates chromosome bipolar attachment. Mol Biol Cell. 2013 Mar;24(5):566-77. doi: 10.1091/mbc.E12-07-0552.
Kassardjian A, Rizkallah R, Riman S, Renfro SH, Alexander KE, Hurt MM. The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle. PLoS One. 2012;7(11):e50645. doi: 10.1371/journal.pone.0050645.
Riman S., Rizkallah, R., Kassardjian, A., Alexander K.E., Lüscher, B., and Hurt, M.M. Phosphorylation of the Transcription Factor YY1 by CK2a Prevents Cleavage by Caspase 7 during Apoptosis. Mol. Cell. Biol. 2012; 32(4): 797-807.
Moseley S.C., Rizkallah R., Tremblay D.C., Anderson B.R., Hurt M.M., Chadwick B.P. YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas. Nucleic Acids Res. 2012 Feb 1;40(4):1596-608.
Rizkallah R, Alexander KE, Hurt MM. Global mitotic phosphorylation of C2H2 zinc finger protein linker peptides. Cell Cycle. 2011 Oct 1;10(19):3327-36.
Rizkallah R, Alexander K.E., Kassardjian A, Lüscher B, Hurt M.M. (2011) The Transcription Factor YY1 Is a Substrate for Polo-Like Kinase 1 at the G2/M Transition of the Cell Cycle. PLoS ONE 6(1): e15928. doi:10.1371/journal.pone.0015928
Rizkallah, R. and Hurt, M.M. Regulation of the Transcription Factor YY1 in Mitosis through Phosphorylation of Its DNA-binding Domain. Mol. Biol. Cell 2009; 20(22):4766-4776.
Hurt M.M., Littles A.B. The price of changing the status quo. Acad Med. 2009 Feb;84(2):151.
Beyrouthy M.J., Alexander K.E., Baldwin A., Whitfield M.L., Bass H.W., McGee D., and Hurt M.M. (2008) Identification of G1-Regulated Genes in Normally Cycling Human Cells. PLoS ONE 3(12): e3943. doi:10.1371/journal.pone.0003943
Hurt M.M., Harris J.O. Founding a new College of Medicine at Florida State University. Acad Med. 2005 Nov;80(11):973-9.
Krippner-Heidenreich, A., Walsemann, G., Beyrouthy, M., Speckgens, S., Kraft, R., Thole, H., Talanian, R., Hurt, M.M., and Lüscher, B. (2005) Caspase-dependent regulation and subcellular redistribution of the transcription modulator YY1 during apoptosis. Molecular and Cellular Biology 25 (9): 3704-3714.
Palko L., Bass H.W., Beyrouthy M.J., and Hurt M.M. The Yin Yang-1 (YY1) protein undergoes a DNA replication-associated switch in localization from the cytoplasm to the nucleus at the onset of S phase. Journal of Cell Sci. 2004; 117(3):465-476.
Whitfield, M.L., Sherlock, G., Saldanha, A., Murray, J., Ball, C., Alexander, K., Matese, J., Perou, C., Hurt, M.M., Brown, P., and Botstein, D. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell. 13: 1977-2000.
Eliassen, K., Baldwin, A., Sikorski, E., and Hurt, M.M. 1998. Role for a YY1 binding element in replication-dependent mouse histone gene expression. Mol. Cell. Biol. 18:7106-7118.