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Michael Blaber Ph.D.

Michael Blaber Ph.D.

Professor

michael.blaber@med.fsu.edu
(850) 644-3361
Main Campus

Job Description

Research, Teaching and Service
A complete Curriculum Vitae can be found here.

Biosketch

Dr. Blaber graduated with a B.A. in Biochemistry/Molecular Biology from the University of California at Santa Barbara in 1980. At the time, molecular biology was a new field, and UCSB was one of the few institutions that offered an undergraduate degree in this area. After graduation, Blaber was recruited by Genentech Inc. as a Research Assistant in Protein Chemistry. Genentech was one of the first biotech companies, and Blaber was the 120th employee. After five exciting years studying the properties of recombinant human proteins, Blaber left Genentech and entered the Ph.D. program in the Department of Biological Sciences in the College of Medicine at UC Irvine (in the laboratory of Dr. Ralph A. Bradshaw). During this time Blaber studied structure/function relationships of serine protease proteins, and was supported by an undergraduate NIH fellowship and an Earl C. Anthony dissertation fellowship. After graduating, Blaber was a Postdoctoral Fellow in the laboratory of Dr. Brian Matthews, Howard Hughes Medical Institute, University of Oregon where he was supported by an NIH Postdoctoral Fellowship to study protein structure and stability relationships. Upon completing his Postdoctoral work, Blaber joined the Department of Chemistry at FSU as an Assistant Professor, receiving a University Teaching Award in 1999 for undergraduate chemistry instruction. Blaber subsequently earned tenure in the FSU College of Arts and Sciences, and promotion to Associate Professor in 2000. In fall 2005 he joined the Department of Biomedical Sciences in the FSU College of Medicine. In 2006 he was tenured in the FSU College of Medicine, and in 2007 he was promoted to Professor, and also received the 2007 Outstanding Senior Faculty Researcher Award. In 2009 Blaber received the E.K. Frey/E. Werle Gold Medal for research in the area of Kallikrein-related peptidases. Blaber was awarded the 2013 Outstanding Senior Faculty Researcher Award. To date, 18 patents related to Blaber's research have been awarded or are pending. Intellectual property derived from his research at FSU has been licensed to Trefoil Therapeutics Inc. and Lomir Biomedical Inc. A total of 8 Postdoctoral Fellows, 20 Graduate Students, 2 Medical Students, and 69 Undergraduate Students have been trained in his laboratory.

Education

1976-1980 BA Biochemistry/Molecular Biology, University of California at Santa Barbara
1985-1990 Ph.D. Biological Chemistry, University of California at Irvine

Service

Editorial Board:
Editorial Board, Journal of Pharmaceutical Sciences (2017-2019)
Editorial Board, Journal of Proteins and Proteomics (2008-2020)
Editorial Board, Archives of Biochemistry & Biophysics (2010-2018)
Editorial Advisory Board, Protein Science (2003-2009)
Editorial Board, Molecular and Cellular Proteomics (2001-2007)

FSU Faculty Senate (2014-2016)
Chair, American Chemical Society, Florida Section (2004)

Honors/Awards

Awards:
Outstanding Senior Faculty Researcher Award, Department of Biomedical Sciences, FSU (2013)
E.K. Frey/E. Werle Gold Medal, FSU 2009
Outstanding Senior Faculty Researcher Award, Department of Biomedical Sciences, FSU (2007)
Faculty Ranking #1, Department of Chemistry & Biochemistry, FSU (2002)
University Teaching Award, FSU (1999)
First Year Assistant Professor Award, FSU (1995)
N.I.H. Postdoctoral Fellowship GM13709-01, Institute of Molecular Biology, University of Oregon, Eugene OR (3/90-2/93)
N.I.H. Predoctoral Fellowship GM07134-11, University of California, Irvine CA (9/86-8/89)
Earl C. Anthony Dissertation Fellowship, University of California, Irvine CA (9/89-12/89)

Patents:
17 US patents, 1 European patent (issued/pending)

Memberships

American Chemical Society, Biophysical Society, Protein Society, American Association for the Advancement of Science (AAAS), Federation of American Societies for Experimental Biology (FASEB), International Union of Crystallographers (IUCr), American Society for Biochemistry & Molecular Biology (ASBMB)

Research Focus

Protein structure, stability and folding; Protein design of human fibroblast growth factor-1 for therapeutic application; Protein evolution.

Publications

Folding Nucleus Structure Persists in Thermally-aggregated FGF-1, but a Symmetric Mutant sharing the Folding Nucleus does not Aggregate, Longo, L.M., Gao, Y., Tenorio, C.A., Wang, G., Paravastu, A.K. and Blaber, M. (2017 submitted)

An S116R Phosphorylation Site Mutation in Human FGF-1 Differentially Affects Mitogenic and Glucose Lowering Activities, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Suh, J.M., Atkins, A.R., Downes, M., Evans, R.M., Tenorio, C.A., Bienkiewicz, E. and Blaber, M., J. Pharm. Sci. 105, 3507-19 (2016)

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "2nd Generation" Therapeutic Application, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Sutherland, M.A., Tenorio, C. and Blaber, M., J. Pharm. Sci. 105, 1444-53 (2016)

Evolution of a Protein Folding Nucleus, Xia, X., Longo, L.M., Sutherland, M.A. and Blaber, M., Protein Science 25, 1227-40 (2016) “Protein Evolution and Design” special issue

Accelerated Healing in NONcNZO10/LtJ Type 2 Diabetic Mice by FGF 1, Blaber, S.I., Diaz, J. and Blaber, M., Wound Repair and Regeneration 23, 538-49 (2015)