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Myra M Hurt Ph.D.

Professor and Senior Associate Dean for Research and Graduate Programs

myra.hurt@med.fsu.edu
850-644-8935

Biosketch

Dr. Hurt has been involved in medical education for more than 25 years, first at the University of Tennessee and later at the Baylor College of Medicine. She came to FSU in 1987 and joined the team of professors teaching biochemistry to medical students in the Program in Medical Sciences (PIMS). In 1992, Dr. Hurt became the Director of PIMS, working closely with the University of Florida College of Medicine to assure the quality of the first-year medical education program at FSU. In 1992, Dr. Hurt joined the faculty of the department of biological science, where she earned tenure. She taught microbiology to undergraduates, advanced molecular biology to graduate students, and taught an Honors Seminar in the FSU Honors Program. She served as acting dean of the new College of Medicine from 2000 to 2001. She was associate dean for student affairs, admissions and outreach from 2001-2004 and assumed the role of associate dean for research and graduate programs in 2004. She was named senior associate dean for research and graduate programs in 2009. She is the founding faculty member of the College of Medicine, and leads a molecular biology research group engaged in dissecting the regulation of cellular division at the molecular level. She enjoys working with students in the laboratory and has directed the research of eight students who earned the Ph.D. degree, with another student currently working toward the Ph.D. and one who earned an M.S., and over 25 undergraduate researchers at FSU since 1992.

Education

B.S., Biology, Henderson State University, Arkadelphia, Ark.

Ph.D., Microbiology, University of Tennessee Center for the Health Sciences, Memphis, Tenn.

Postdoctoral, Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas

Service

Scientific Review:
Grant Reviewer, National Science Foundation, EPSCOR, Biochemical Genetics, and Israel Science Foundation
Journal Reviewer, Genome, Molecular Biology Reports, Nucleic Acids Research, Gene, Journal of Cellular Biochemistry, Proceedings of the National Academy of Sciences, and Academic Medicine.
Research Committee, State of Florida Biomedical Research Advisory Committee, 2006-2012
FSU Council on Research and Creativity, 2004-present; Chair, 2010-present.

Medical Student Admissions:
University of Florida College of Medicine, 1991-1993
FSU Program in Medical Sciences, 1989-2000; FSU College of Medicine, 2000-2005.

Curriculum Committee Service:
University of Florida College of Medicine, 1992-2000, Biochemistry Subcommittee, 1993-1995
FSU Dept. of Biological Science, 1991-2000
FSU PIMS, 1991-2001; FSU College of Medicine, 2000-2004.

Accreditation:
FSU PIMS LCME Working Group, Chair, 1992-1993
PIMS LCME Accreditation Task Force, 1998-2000
College of Medicine Accreditation Task Force, 2000-2005; 2008-2010

FSU Faculty Searches:
PIMS, 1993, Chair-1994, 1999,2000; Biological Science, 1996, Chair Search 1997
College of Engineering, Biomedical Engineering, 2000
College of Social Sciences Epidemiologist Search, 2001
College of Medicine Dean Search, Chair, 2000-2001, COM Faculty Search, 2000-2002
Biomedical Sciences Faculty Search, 2002-2006
Biomedical Sciences Chair, 2009-2010
Medical Humanitites and Social Sciences Chair Search, 2009-2010

Faculty Peer Evaluation:
FSU Dept. of Biological Science Faculty Evaluation Committee, 1994-1995
Teaching Incentive Program Award Committee, 1995
Junior Faculty Mentorship Committees 1997-2001
COM Biomedical Sciences Faculty Reviews, 2003, 2004
COM Tenure and Promotion Committee, 2001-present
FSU Tenure and Promotion Committee, 2004-present.

Building Committees:
FSU PIMS Suite, Duxbury Hall, Chair, 1992-1993
FSU College of Medicine Transitional Space Renovation Committee, 2001-2002
FSU College of Medicine Building Committee, Chair, 2001-2006

Honors/Awards

NIH Medical Genetics Trainee, Departments of Medicine, Pediatrics and Cell Biology, Baylor College of Medicine, Houston, Texas, 1978-1981

Robert A. Welch Fellow, Department of Cell Biology, Baylor College of Medicine, Houston, Texas

Visiting Professorships for Women Award, National Science Foundation, 1987-1989

Kappa Delta Sorority Excellence in Teaching Award, Florida State University, 1993

Florida Teaching Incentive Award, Florida State University, 1996

Harvard Macy Institute Leaders in Medical Education, 1999

Honors Program Teaching Excellence Recognition, Florida State University, 2000

Visiting Professor, Harvard Macy Institute, Harvard Medical School, 2003-present

Molecular Biology of the Cell Paper of the Year Award: Whitfield, M.L., Sherlock, G., Salanha, A., Murray, J., Ball, C., Alexander, K., Matese, J., Perou, C., Hurt, M., Brown, P., and Botstein, D. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell.13:1977-2000, 2003 Jim King Leadership Award for the State of Florida, 2011.

Memberships

Member, American Association for the Advancement of Science, 1987-present
Member, American Society for Microbiology, 1992-present
Member, American Society for Biochemistry and Molecular Biology, 2002-present

Research Focus

Dr. Hurt studies the regulation of mammalian gene expression, specifically those events controlling transcription initiation in general and in the cell division cycle in particular. Her laboratory is examining the cellular signals that control the up-regulation of the histone gene family in late G1 of the cell cycle, an event which is tightly coupled to onset of DNA synthesis. These cellular events occur at the point of the cell cycle where the cell makes initial decisions leading to proliferation or nonproliferation, contributing to the understanding of the molecular basis of cancer. A current focus is the pattern post-translational modifications of the transcription factor YY1 in the cell cycle and effects on YY1 function.

Publications

Riman S., Rizkallah, R., Kassardjian, A., Alexander K.E., Lüscher, B., and Hurt, M.M. Phosphorylation of the Transcription Factor YY1 by CK2a Prevents Cleavage by Caspase 7 during Apoptosis. Mol. Cell. Biol. 2012; 32(4): 797-807.

Moseley S.C., Rizkallah R., Tremblay D.C., Anderson B.R., Hurt M.M., Chadwick B.P. YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas. Nucleic Acids Res. 2012 Feb 1;40(4):1596-608.

Rizkallah R, Alexander KE, Hurt MM. Global mitotic phosphorylation of C2H2 zinc finger protein linker peptides. Cell Cycle. 2011 Oct 1;10(19):3327-36.

Rizkallah R, Alexander K.E., Kassardjian A, Lüscher B, Hurt M.M. (2011) The Transcription Factor YY1 Is a Substrate for Polo-Like Kinase 1 at the G2/M Transition of the Cell Cycle. PLoS ONE 6(1): e15928. doi:10.1371/journal.pone.0015928

Rizkallah, R. and Hurt, M.M. Regulation of the Transcription Factor YY1 in Mitosis through Phosphorylation of Its DNA-binding Domain. Mol. Biol. Cell 2009; 20(22):4766-4776. Hurt M.M., Littles A.B. The price of changing the status quo. Acad Med. 2009 Feb;84(2):151.

Beyrouthy M.J., Alexander K.E., Baldwin A., Whitfield M.L., Bass H.W., McGee D., and Hurt M.M. (2008) Identification of G1-Regulated Genes in Normally Cycling Human Cells. PLoS ONE 3(12): e3943. doi:10.1371/journal.pone.0003943

Hurt M.M., Harris J.O. Founding a new College of Medicine at Florida State University. Acad Med. 2005 Nov;80(11):973-9.

Krippner-Heidenreich, A., Walsemann, G., Beyrouthy, M., Speckgens, S., Kraft, R., Thole, H., Talanian, R., Hurt, M.M., and Lüscher, B. (2005) Caspase-dependent regulation and subcellular redistribution of the transcription modulator YY1 during apoptosis. Molecular and Cellular Biology 25 (9): 3704-3714.

The Yin Yang-1 Protein Undergoes a DNA-Replication Associated Switch in Localization from the Cytoplasm to the Nucleus at the Onset of S Phase. Palko, L., Bass, H., Beyrouthy, M., and Hurt, M. 2004. Journal of Cell Science 117(3):465-476.

Whitfield, M.L., Sherlock, G., Saldanha, A., Murray, J., Ball, C., Alexander, K., Matese, J., Perou, C., Hurt, M., Brown, P., and Botstein, D. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell. 13: 1977-2000.

Eliassen, K., Baldwin, A., Sikorski, E., and Hurt, M. 1998. Role for a YY1 binding element in replication-dependent mouse histone gene expression. Mol. Cell. Biol. 18:7106-7118.

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