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Yuan Wang Ph.D.

Yuan Wang Ph.D.

Assistant Professor
(850) 645-4934
Main Campus


I am interested in development and plasticity of neuronal circuits and their pathology in neurodevelopmental disorders and neurodegeneration. Prior to joining the faculty of Florida State University College of Medicine in 2015, I completed postdoctoral fellowships at the University of California at San Diego and University of Washington.


Post-Doctoral training, University of Washington
Post-Doctoral training, University of California, San Diego
Ph.D., Chinese Academy of Sciences; Major: Biophysics


FSU College of Medicine Service
2015-2017: Faculty Council representative.
2016-cur: BMS Seminar Committee
2016-cur: BMS Faculty Development Committee

Ad-hoc Reviewer
National Institute of Health (NIH), Proceedings of the National Academy of Sciences of the United States of America (PNAS), Journal of Neuroscience, PLOS One, Brain Research Bullet, Visual Neuroscience


Association for Research in Otolaryngology (ARO), Society for Neuroscience (SfN)

Research Focus

My research interests are brain development and regulation. We are particularly interested in roles of the fragile X mental retardation protein (FMRP) in developing auditory circuits for sound localization and scene analyses. Loss of FMRP results in abnormal neurons in the brain and the fragile X syndrome, the leading known genetic cause of autism. We apply genetic, molecular, and cellular approaches to investigate neuronal structure and function in normal and abnormal brains.


Sakano H, Zorio DAR, Wang X, Ting YS, Noble WS, MacCoss MJ, Rubel EW, Wang Y (2017). Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein. J Comp Neurol. 2017 Jul 7. doi: 10.1002/cne.24281. [Epub ahead of print]

Wang Y, Zorio DAR, Karten HJ (2017). Heterogeneous organization and connectivity of the chicken auditory thalamus (Gallus gallus). J Comp Neurol. 2017 Jun 14. doi: 10.1002/cne.24262. [Epub ahead of print]

Zorio DA, Jackson CM, Liu Y, Rubel EW, Wang Y (2017). Cellular distribution of the fragile X mental retardation protein in the mouse brain. J Comp Neurol 525:818-849.

Wang X, Hong H, Brown DH, Sanchez JT, Wang Y (2017). Distinct Neural Properties in the Low-Frequency Region of the Chicken Cochlear Nucleus Magnocellularis. eNeuro. 2017 Apr 11;4(2).

Weatherstone JH, Kopp-Scheinpflug C, Pilati N, Wang Y, Forsythe ID, Rubel EW, Tempel BL (2017). Maintenance of neuronal size gradient in MNTB requires sound-evoked activity. J Neurophysiol 117(2):756-766.

Sanchez JT, Wang Y, Lu Y, Burger MR, Seidl AH, Rubel EW (2017). Nucleus Laminaris. In: Shepherd G, Addona D, editors. Handbook of Brain Microcircuits. New York: Oxford University Press; 2017.

Wang Y, Rubel EW (2016). Modification of dendritic architecture after function. In: Emoto K, Wong R, Huang E, Hoogenraad C, editors. Dendrites: Development and Disease Tokyo: Springer Japan; 2016. 245-270p.

Beebe K, Wang Y, Kulesza RJ (2014). Distribution of fragile X mental retardation protein in the human auditory brainstem. Neuroscience 273:79-91.

Wang Y, Sakano H, Beebe K, Brown MR, Laat R, Bothwell M, Kulesza RJ, Rubel EW (2014). Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons -- a comparative study in the alligator, chicken, gerbil, and human. J Comp Neurol 522:2107-28.

McBride EG, Rubel EW, Wang Y (2013). Afferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2. J Comp Neurol 521:1165-1183.

Polley DB, Seidl AH, Wang Y, Sanchez JT (2013). Functional circuit development in the auditory system. In: Rubenstein JLR and Rakic P (ed.) Comprehensive developmental neuroscience: Neural Circuit Development and Function in the Brain, volume 3, pp. 21-39 Amsterdam: Elsevier.

Seidl AH*, Sanchez JT*, Schecterson L*, Tabor KM*, Wang Y*, Kashima DT*, Fraser SE, Huss D, Poynter G, Lansford R, Rubel EW (2013). Validation of the transgenic quail as a model for research in the avian nervous system – a comparative study of the auditory brainstem. J Comp Neurol. 521:5-23. *Joint first authors.

Wang Y, Rubel EW (2012). In vivo reversible regulation of dendritic patterning by afferent input in bipolar auditory neurons. J Neurosci 32:11495-11504. Selected in This Week in The Journal.

Sanchez JT, Wang Y, Rubel EW, Barria A (2010). Development of glutamatergic synaptic transmission in binaural auditory neurons. J Neurophysiol 104:1774-1789.

Wang Y, Brzozowska-Prechtl A, and Karten HJ (2010). Laminar and columnar auditory cortex in avian brain. Proc Natl Acad Sci USA 107:12676-12681.

Wang Y, Karten HJ (2010). Three subdivisions of the auditory midbrain in chicks (Gallus gallus) identified by their afferent and commissural projections. J Comp Neurol 518:1199-1219.

Wang Y*, Sanchez JT*, Rubel EW (2010). Nucleus laminaris. In: Shepherd G and Addona DD, editors. Handbook of Brain Microcircuits. New York: Oxford University Press. pp 224-233. *Joint first authors.

Wang Y, Cunningham DE, Tempel BL, Rubel EW (2009). Compartment-specific regulation of plasma membrane calcium ATPase type 2 in the chick auditory brainstem. J Comp Neurol 514:624-640.

Wang Y, Rubel EW (2008). Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity. Neuroscience 154:381-389.

Gruberg E, Dudkin E, Wang Y, Marín G, Salas C, Sentis E, Letelier J, Mpodozis J, Malpeli J, Cui H, Ma R, Northmore D, Udin S (2006). Influencing and interpreting visual input: the role of a visual feedback system. J Neurosci 26:10368-10371.

Wang Y*, Luksch H*, Brecha NC, Karten HJ (2006). Columnar projections from the cholinergic nucleus isthmi to the optic tectum in chicks (Gallus gallus): a possible substrate for synchronizing tectal channels. J Comp Neurol 494:7-35. *Joint first authors.

Wang Y, Major DE, Karten HJ (2004). Morphology and connections of nucleus isthmi pars magnocellularis in chicks (Gallu gallus). J Comp Neurol 469:275-297.