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Role of vimentin intermediate filaments in collagen synthesis

Start Date: 10/06/2010
End Date: 10/06/2010
Time: 12:00 -1:00 pm
Location: Room 1302 of the Biomedical Sciences Building
Area: Central Campus
City: Tallahassee
State: Florida
URL: More event information
Event Type: Seminar
Event Sponsor: Department of Biomedical Sciences

The intermediate filament vimentin has long been regarded to have mainly structural role; consequently, its non-structural functions are only beginning to be discovered. My presentation will be about a novel function of vimentin as a key component of the post-transcriptional regulation of type I collagen gene expression. Using affinity purification techniques, we identified vimentin as a major interacting protein with collagen mRNAs and LARP-6. However, vimentin’s role in synthesis of type I collagen hasn’t been previously reported. The results I will present show that vimentin filaments associate with α1(I) and α2(I) collagen mRNAs in a LARP6 dependent manner and that this association is needed for the stability of collagen mRNAs. These findings can help to explain the impaired wound healing phenotype observed in vimentin deficient mice and can be utilized for anti-fibrotic treatment approaches in the management of several incurable fibro-proliferative diseases.

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