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The temporal control of spindle elongation in budding yeast

Start Date: 09/22/2010
End Date: 09/22/2010
Time: 12:00 -1:00 pm
Location: Room 1302 of the Biomedical Sciences Building
Area: Central Campus
City: Tallahassee
State: Florida
URL: More event information
Event Type: Seminar
Event Sponsor: Department of Biomedical Sciences

Spindle elongation occurs after sister chromatid separation and is essential to segregate sister chromatids into the daughter cells. In budding yeast, cells form spindle during S phase, but the spindle elongates after the metaphase-anaphase transition. It remains poorly understood how cells coordinate spindle elongation and sister chromatid separation. Our recent data indicate that the activation of Clb2-Cdk1, the major mitotic CDK (cyclin-dependent kinase), triggers spindle elongation by counteracting the S-phase CDK (Clb5-Cdk1). Mitotic CDK induces the release of a protein phosphatase Cdc14, which reverses the phosphorylation imposed by S-phase CDK to promote spindle elongation. We found that the reversal of the phosphorylation of Spc110, a S-phase substrate at the spindle pole, is critical for spindle elongation.

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