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CONTACT: Ron Hartung
(850) 645-9205; ronald.hartung@med.fsu.edu
By Ron Hartung
October 2009
FSU RESEARCHER WINS $2.4M IN GRANTS TO PURSUE EARLY DETECTION OF
AUTISM
NIH Grants Will Help Wetherby Develop Screening Tool, Study Cultural
Differences
TALLAHASSEE, Fla. -- A Florida State University College of Medicine
researcher has been awarded two separate grants from the National
Institutes of Health (NIH) totaling $2.4 million to continue her
work in detecting autism in children as young as 18 months.
Amy Wetherby is director of the Autism Institute in the College of
Medicine. For a decade her FIRST WORDS® Project has screened
children to identify early red flags of various autism spectrum
disorders (ASD). Among those red flags are a child’s reluctance to
look at the face or eyes of others; a delay in the use of gestures,
sounds and words; a tendency not to share excitement or interests;
and a fixation on certain objects.
The younger the child, the more subtle the red flags but the greater
the chances of working with the family to lessen the negative
effects. People with autism can have many strengths, Wetherby said,
citing Albert Einstein as a prime example. For some people, however,
autism is a severe disability.
“The symptoms themselves can actually impair learning,” Wetherby
said. “Just like cancer, the earlier we can catch it, the far better
the outcomes.”
In the United States, she said, most children who have autism are
usually not identified until somewhere between ages 3 and 5. The
American Academy of Pediatrics recommends screening children between
ages 18 and 24 months. The problem, Wetherby said, is that there is
no well-validated, ASD-specific screener for that age group for use
in pediatric settings.
A $1.9 million, two-year grant from the NIH’s Eunice Kennedy Shriver
National Institute of Child Health and Human Development will fund
research that aims to develop such a screener. Wetherby’s
collaborators are Eva Petkova at the New York University Child Study
Center and Catherine Lord at the University of Michigan Autism and
Communication Disorders Center.
A total of 600 children will participate. The researchers will study
several different screening and evaluation measures that they
developed. Some are designed to help parents detect red flags of ASD.
Other are designed to help pediatricians and other professionals.
“By improving and streamlining early screening and diagnosis of ASD
in 18- to 24-month-old children, the findings of this study will
have important implications for earlier access to intervention,” the
grant proposal stated.
Sometimes a screening tool that works well in one culture does not
work as well in another. Wetherby’s two-year grant from the National
Institute on Deafness and Other Communication Disorders, which
totals more than $465,000, will fund research that may lead to
culturally sensitive screening and evaluation methods.
Children of African-American and Latino families in the United
States, she said, are usually not diagnosed with autism until
they’re 4 to 6 years old, a full year later than other children.
“We’re trying to address that disparity by studying cultural
differences in the early signs of autism,” Wetherby said.
Researchers will compare children of Latino immigrants in Immokalee,
Fla., with children from the KwaZulu-Natal province of South Africa
and children from Leon County, Fla. The College of Medicine has a
health education site in Immokalee, and a former doctoral student of
Wetherby’s, Nola Chambers, lives in South Africa. Richard Grinker,
an anthropologist from George Washington University, is also a
collaborator.
The American Recovery and Reinvestment Act provided the funding for
the NIH grants. None of this stimulus money will be spent in Africa,
Wetherby said, but in the United States it will pay for researchers
and will pay families $50 for participating in assessments. Wetherby
thinks it’s a good investment.
“Now we have this big chunk of money that is going to help us
accelerate our findings,” she said, “which is really the idea of the
stimulus money -- to use it to accelerate science.”
Both grants are funded through Aug. 31, 2011. For more information
on the FIRST WORDS® Project, visit http://firstwords.fsu.edu.
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