Movement disorders are major targets of our clinical and basic science research program. Our goal is to develop novel methods of diagnosis and treatment of these disorders. Our ongoing research programs focus on the developmental origins of childhood onset dystonias. We are planning a clinical research program using state of the art genetic, proteomic, as well as structural and functional brain imaging technologies for identification of biomarkers, and development of a cure for dystonia. We expect to broaden our efforts to include the neurobiological mechanisms of heritable and sporadic forms of movement disorders.