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Gregg Stanwood Ph.D.

Associate Professor

gregg.stanwood@med.fsu.edu
(850) 644-2271
Main Campus

Biosketch

I am a developmental neuropharmacologist and behavioral neuroscientist. Studies in my lab investigate the developmental origins of brain disorders through careful assessments of brain developmental trajectories following genetic and environmental perturbations. We are particularly interested in the long-lasting neuro(mal)adaptations that can be induced by environmental stressors and drugs during critical windows of development. To do this we integrate multidisciplinary studies of brain architecture, cell signaling and behavioral pharmacology. Prior to joining the faculty of Florida State University College of Medicine, I completed postdoctoral fellowships at the University of Pittsburgh and was on the faculty at Vanderbilt University.

Education

1992-1997: Ph.D. in Neuroscience, University of Pennsylvania, Philadelphia

1987-1991: B.A. in Biology and Psychology, summa cum laude, Temple University, Philadelphia

Service

Editorial Board:
Reviewing Editor, Frontiers in Behavioural Neuroscience (2007 – present)
Editorial Board, Neurotoxicology and Teratology (2011 – present)
Editorial Board, Developmental Neuroscience (2011 – present)
Associate Editor for Special Issues, Developmental Neuroscience (2013 – present)

Peer Review:
Ad hoc Study Section Member, ZRG1 MDCN-G (AED) (March 2009)
Ad hoc Study Section Member, ZRG1 IFCN-L (96) M (AED) (July 2009)
Ad hoc Study Section Member, Developmental Brain Disorders (June 2009, October 2010, June 2011, June 2011, October 2011, June 2013)
Ad hoc Study Section Member, BRAINS (ZMH1 ERB-L) (June 2009, March 2010, March 2011)
Ad hoc Study Section Member, ZMH1 ERB-L (05) S (teleconference) (July 2011)
Ad hoc Study Section Member, MDCN J(04) (teleconference) (November 2012)
Ad hoc Study Section Member, ZMH1 ERB-L (02) S (teleconference) (November 2013)
Institutional Development Grant Reviewer, North Carolina Biotechnology Center (2008)
The Netherlands Organisation for Health Research and Development (2012, 2013)
NWO Council for the Earth and Life Sciences (2013)

Honors/Awards

1987-1991: Temple University Outstanding Achievement Scholar, summa cum laude
1993-1996: NSF Predoctoral Fellowship
1997-1998: NRSA Postdoctoral Training Grant Fellowship
1998-2000: PhRMA Foundation Pharmacology/Morphology Postdoctoral Fellowship
2010: American College of Neuropsychopharmacology Travel Fellow
2013: Vanderbilt Distinguished Faculty Award
2014: Mentor of the Year, Vanderbilt Neuroscience Graduate Group

Memberships

American Society for Pharmacology and Experimental Therapeutics (ASPET), Society for Neuroscience (SfN), Neurobehavioral Teratology Society (NBTS)

Research Focus

The Stanwood lab's research interests are in the developmental basis of brain disorders.

Publications

Selected:

Frederick, A.L., Yano, H., Triflieff, P., Vishwasrao, H.D., Biezonski, D., Mészáros, J., Sibley, D.R., Kellendonk, C., Sontag, K.C., Graham, D.L., Colbran, R.J., Stanwood, G.D. & Javitch, J. Evidence against dopamine D1/D2 receptor heteromers, Molecular Psychiatry, 2015, Jan 6. doi: 10.1038/mp.2014.166. [Epub ahead of print]. (Stanwood and Javitch are co-senior authors).

Graham, D.L., Durai, H.H., Garden, J.D., Cohen, E., Echevarria, F.D. & Stanwood, G.D. Loss of dopamine D2 receptors increases parvalbumin-positive interneurons in the anterior cingulate cortex, 2014, ACS Chemical Neuroscience, Nov 24. [Epub ahead of print].

Mergy, M.A., Gowrishankar, R., Gresch, P.J., Gantz, S.C., Williams, J.T., Davis, G.L., Wheeler, C.A., Stanwood, G.D., Hahn, M.K. & Blakely, R.D. The rare dopamine transporter variant Val559 disrupts dopamine neuronal function, changes behavior and alters in vivo responses to psychostimulants, PNAS, 2014, Nov 4;111(44):E4779-88. doi: 10.1073/pnas.1417294111.

Coke-Murphy, C., Buendia, M.A., Saborido, T.P. & Stanwood, G.D. Simple shelter-style environmental enrichment alters behavior in mice, Translational Neuroscience, 2014, 5: 185-96.

Kocalis, H.E., Hagan, S.L., George, L., Turney, M.K., Siuta, M.A., Laryea, G.N., Morris, L.C., Muglia, L.J., Printz, R.L., Stanwood, G.D. & Niswender, K.D. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Molecular Metabolism, 2014, 3:394-407.

Graham, D.L, Erreger K., Galli A. & Stanwood, G.D.. GLP-1 analog attenuates cocaine reward, Molecular Psychiatry, 2013 Sep;18(9):961-2. doi: 10.1038/mp.2012.141. Epub 2012 Oct 23. PMID: 23089631.

Ross, E.J., Graham, D.L., Money, K.M. & Stanwood, G.D. Developmental consequences of fetal exposure to drugs: what we know and what we still must learn, Neuropsychopharmacology Reviews, 2014, Jun 18. doi: 10.1038/npp.2014.147. [Epub ahead of print].

Money, K.M. & Stanwood, G.D. Developmental origins of brain disorders: roles for dopamine, Frontiers in Cellular Neuroscience, 2013 Dec 19; 7:260. PMID: 24391541.

Reddy, I.A., Stanwood, G.D. & Galli A. Moving beyond energy homeostasis: New roles for glucagon-like peptide-1 in food and drug reward, Neurochemistry International, 2013 Oct 16. pii: S0197-0186(13)00259-3. doi: 10.1016/j.neuint.2013.10.003., PMID:24140429.

Kocalis H.E., Turney M.K., Printz R.L., Laryea G.N., Muglia L.J., Davies S.S., Stanwood, G.D., McGuinness O.P. & Niswender K.D. Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity. PLoS One. 2012, 7(8):e42981, Epub 2012 Aug 20, PMID: 22916190.

Killinger, C.E., Robinson, S. & Stanwood, G.D. Subtle biobehavioral effects produced by paternal cocaine exposure, Synapse, 2012, 66:902-8, PMID:22807092.

Frederick, A.L., Saborido, T.P. & Stanwood, G.D. Neurobehavioral phenotyping of G?q knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair, Frontiers in Behavioral Neuroscience, 2012, 6:29. Epub 2012 Jun 19, PMID:22723772.

Jackson, C.R., Ruan, G.X., Aseem, F., Abey, J., Gamble, K., Stanwood, G., Palmiter, R., Iuvone, P.M. & McMahon, D. Retinal dopamine mediates multiple dimensions of light-adapted vision, Journal of Neuroscience, 2012, 32:9359-9368, PMID:22764243.

McLaughlin, B., Buendia, M.A., Saborido, T.P., Kleman, A.M. & Stanwood, G.D. C-terminus of heat shock cognate 70 Interacting Protein (CHIP) haploinsufficiency produces specific behavioral impairments, PLoS ONE, 7(5):e36340. Epub 2012 May 11, PMID: 22606257.

Carpenter, A.C., Saborido, T.P. & Stanwood, G.D. Development of behavioral responses in dopamine transporter deficient mice, Developmental Neuroscience, 2012, 34(2-3):250-7, PMID: 22572477.

Swant, J., Chirwa, S., Stanwood, G. & Khoshbouei, H. Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus, PLoS ONE, 5: e11382, 2010, PMID: 20614033.

Siuta, M., Robertson, S., Kocalis, H., Saunders, C., Gresch, P., Khatri, V., Shiota, C., Kennedy, J.P., Lindsley, C., Daws, L., Polley, D., Veenstra-Vanderweele, J., Stanwood, G.D., Magnuson, M., Niswender, K. & Galli, A. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal Rictor null mice, PLoS Biology, 8:e1000393, 2010, PMID: 20543991.

Neely, M.D., Stanwood, G.D. & Deutch, A.Y. Combination of DiOlistic labeling with retrograde tract tracing and immunohistochemistry, Journal of Neuroscience Methods, 184: 332-6, 2009, PMID: 19712695.

Stanwood, G.D., Leitch, D.B., Savchenko V., Wu, J., Fitsanakis, V.A., Anderson, D.J., Stankowski, J.N., Aschner, M. & McLaughlin, B. Chronic manganese exposure in mice is neurotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia, 110: 378-89, Journal of Neurochemistry, 2009, PMID: 19457100.

Thompson, B.L., Levitt, P. & Stanwood, G.D. The effects of prenatal exposure to drugs on brain development and function: implications for policy and education, Nature Neuroscience Reviews, 10:303-12, 2009. PMID: 19277053 Frederick, A.L. & Stanwood, G.D. Drugs, biogenic amine targets and the developing brain, Developmental Neuroscience, 31: 7-22, 2009. PMID: 19372683

Thompson, B.L. & Stanwood, G.D. Pleiotropic effects of neurotransmission during development: modulators of modularity, Journal of Autism and Developmental Disabilities, 39: 260-268, 2009. PMID: 18648918

Stanwood, G.D. & Levitt, P. The effects of monoamines on the developing nervous system, Handbook of Developmental Cognitive Neuroscience 2nd ed., edited by Nelson, C.A. & Luciana, M., MIT Press, 83-94, 2008.

Overton, D.A., Stanwood, G.D., Patel, B.N., Pragada, S.R. & Gordon, M.K. Measurement of the lowest dosage of phenobarbital that can produce drug discrimination in rats, Psychopharmacology, 203: 213-8, 2008, PMID: 19082292.

Couppis, M.H., Kennedy, C.H. & Stanwood, G.D. Alterations in the mesocorticolimbic dopamine system in mouse strains that differ in aggressive behavior, Synapse, 62: 714-725, 2008, PMID: 18651644.

Parlaman, J.P., Thompson, B.L., Levitt, P. & Stanwood, G.D. Pharmacokinetic profile of cocaine following intravenous administration in the female rabbit, European Journal of Pharmacology, 563: 124-29, 2007, PMID: 17383635.

Stanwood, G.D. & Levitt, P. Waved-1 mutant mice are hypersensitive to the locomotor actions of cocaine, Synapse, 61: 259-62, 2007, PMID: 17230552.

Stanwood, G.D. & Levitt, P. Prenatal exposure to cocaine produces unique developmental and long-term adaptive changes in dopamine D1 receptor activity and subcellular distribution, Journal of Neuroscience, 27: 152-7, 2007, PMID: 17202482.

Stanwood, G.D., Parlaman, J.P. & Levitt, P. Genetic or pharmacological inactivation of the dopamine D1 receptor differentially alters the expression of regulator of G-protein signaling (Rgs) transcripts, European Journal of Neuroscience, 24:806-818, 2006, PMID:16930410.

Thompson, B.L., Levitt, P. & Stanwood, G.D. Prenatal cocaine specifically alters spontaneous alternation behavior, Behavioural Brain Research, 164: 107-16, 2005, PMID: 16054247.

Stanwood, G.D., Parlaman, J.P. & Levitt, P. Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant mice, Journal of Comparative Neurology, 487: 270-82, 2005, PMID: 15892099.

Stanwood, G.D. & Levitt, P. Repeated intravenous cocaine exposure produces long-lasting behavioral sensitization in pregnant adults, but behavioral tolerance in their offspring, Neuroscience, 122: 579-583, 2003, PMID: 14622900.