Dr. Nemec earned her Ph.D. at the University of Pittsburgh in 2009 and was a postdoctoral fellow at Yale University School of Medicine until 2014. Dr. Nemec joined the Department of Biomedical Sciences in January 2015.
B.S., Biochemistry and Molecular Biology, Lebanon Valley College
Ph.D., Molecular Toxicology, University of Pittsburgh School of Public Health
Postdoctoral training, Yale University School of Medicine, Department of Therapeutic Radiology
DNA repair; Cancer genetics
Rozacky J, Nemec AA, Sweasy JB, and Kidane D. Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks. Oncotarget. 6: 24474-24487, 2015.
McVeigh TP, Jung S-Y, Kerin MJ, Salzman D, Nallur S, Nemec AA, Dookwah M, Sadofsky J, Paranjape T, Kelly O, Chan E, Miller N, Sweeney KJ, Zelterman D, Sweasy JB, Pilarski R, Telesca D, Slack FJ, and Weidhaas JB. Estrogen withdrawal and multiple breast cancer risk for women with KRAS-variant. Cell Cycle 14: 2091-9. DOI: 10.1080/15384101.2015.1041694.10.1080/15384101.2015.1041694.
Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublie S, and Sweasy JB. A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. PLoS Genet 10:e1004753, 2014.
Nemec AA, Murphy DM, Donigan KA, and Sweasy JB. The S229L DNA polymerase beta human colon tumor variant induces cellular transformation as a result of decreased polymerization efficiency. J Biol Chem 289:13708-16, 2014.
Yamtich JA, Nemec AA*, and Sweasy JB. A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. PLoS Genet 8: e1003052, 2012.
**Featured in Perspective in same issue
Donigan KA, Sun KW, Nemec AA, Murphy DL, Cong X, Northrup V, Zelterman D, and Sweasy JB. The Human POLB Gene is mutated in a high percentage of colorectal tumors. J Biol Chem 287:23830-9, 2012.
Nemec AA, Donigan KA, Murphy DL, Jaeger J, and Sweasy JB. Colon Cancer-Associated DNA Polymerase Beta Variant Induces Genomic Instability and Cellular Transformation. J Biol Chem 287:23840-9, 2012.
Nemec AA, Wallace SS, and Sweasy JB. Variant base excision repair proteins: Contributors to genomic instability. Semin Cancer Biol 20:320-8, 2010.
Nemec AA, Zubritsky LM, and Barchowsky A. Chromium(VI) stimulates Fyn to initiate innate immune gene induction in human airway epithelial cells. Chem Res Toxicol 23: 396-404, 2010.
Nemec AA and Barchowsky A. Signal Transducer and Activator of Transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells. Toxicol Sci 110:212-23, 2009.
Nemec AA, Leikauf GD, Pitt BR, Wasserloos KJ, and Barchowsky A. Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Respir Cell Mol Biol 41:69-75, 2009.
O’Hara KA, Vaghjiani RJ, Nemec AA, Klei LR, and Barchowsky A. Chromium(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck. Biochem J 402:261-9, 2007.
O’Hara KA, Nemec AA, Alam J, Klei LR, Mossman BT, and Barchowsky A. Chromium(VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells. J Cell Physiol 209:113-21, 2006.
Soucy NV, Mayka DD, Klei LR, Nemec AA, Bauer JA, and Barchowsky A. Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice. Cardiovasc Toxicol 5:29-41, 2005.
Gao F, Barchowsky A, Nemec AA, and Fabisiak JP. Microbial Stimulation by Mycoplasma fermentans Synergistically Amplifies IL-6 Release by Human Lung Fibroblasts in Response to Residual Oil Fly Ash (ROFA) and Nickel. Toxicol Sci 81:467-479, 2004.
Nemec AA and Sweasy JB. Pol Β variants and their relation to cancer. In Translesion DNA polymerases: from DNA repair and beyond. Research Signpost. Under release.