Jose R Pinto Ph.D.
Assistant Professor
jose.pinto@med.fsu.edu
850-645-0016
Biosketch
Dr. Jose Pinto earned his Ph.D in 2006 from the Federal University of Rio de Janeiro, his research of study was Muscle Biochemistry and Biophysics. He researched as a Post Doctoral Scholar from 2006 to 2010 at the University of Miami, Miller School of Medicine under the mentoring of Dr. James D. Potter. His post doctoral research focus was on the Molecular Mechanisms of Inherited Cardiomyopathies. In 2010, Dr. Pinto became a Research Assistant Professor until he joined the FSU College of Medicine Biomedical Department in 2011.
Education
Ph.D. in Medical Biochemistry (2006), Federal University of Rio de Janeiro - Brazil
Postdoctoral training with Dr. James D. Potter (2006 - 2010), University of Miami, Miller School of Medicine - USA
Service
Editorial Board:
Frontiers in Cardiac Muscle Physiology
American Journal of Biochemistry
Journal of Biological Chemistry (ad-hoc)
Journal of Molecular and Cellular Cardiology (ad-hoc)
Biochemistry Research International (ad-hoc)
Peer Review responsibilities:
2012 - American Heart Association 2012 fall cycle.
Honors/Awards
Postdoctoral Fellow, American Heart Association (7/2008 - 6/2010).
Travel Award Medical Faculty Association Margaret Whelan Fund, Miller School of Medicine University of Miami (2008).
International Travel Grant, to attend the 50th Biophysical Society Meeting, Salt Lake City (2006).
Grant IUPAB/UNESCO, to attend the 14th International Biophysical Congress, Buenos Aires (2002)
Memberships
Biophysical Society
American Heart Association
Cardiac Muscle Society
American Society for Biochemistry & Molecular Biology (ASBMB)
Research Focus
Cardiac and skeletal muscle regulation and inherited diseases. Molecular basis of striated muscle contraction.
Publications
2013
Bai, F., Caster, H.M., Pinto, J.R., and Kawai, M. Functional properties of cardiomyopathy causing cTnT mutants I79N, ?E96 and ?K210: molecular pathogenesis study. Biophys. J. (London) 104(9): 1979-1988
Venkataraman, R., Baldo, M.P., Hwang, H., Veltri, T., Pinto, J.R., Baudenbacher, F.J., Knollmann, B.C. Myofilament calcium de-sensitization and contractile uncoupling with blebbistatin prevents ventricular tachycardia in mouse hearts with chronic myocardial infarction. J. Mol. Cell. Cardiol. 60C: 8-15, 2013
2012
Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen, S., Miller, T., Parvatiyar, M.S., and Potter, J.D. The Functional Properties of Human Slow Skeletal TnT Isoforms in the Cardiac Muscle Regulation. J. Biol. Chem. 287(44): 37362-70
Tao, G., Levay, A.K., Peacock, J.D., Huk, D.J., Both, S.N., Purcell, N.H., Pinto, J.R., Galantowicz, M.L., Koch, M., Lucchesi, P.A., Birk, D.E. and Lincoln J. Collagen XIV is important for growth and structural integrity of the myocardium. J. Mol. Cell. Cardiol. Nov;53(5): 626-38
Parvatiyar, M., Landstrom, A., Figueiro-Freitas, C., Potter, J.D., Ackerman, M.J., Pinto, J.R. A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation. J. Biol. Chem. 287(38): 31845-31855
Ueta, C.B., Oskouei, B.N., Olivares, E.L., Pinto, J.R., Correa, M.M., Simovic, G., Simonides, W.S., Hare, J.M., Bianco, A.C. Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol. May;26(5): 809-18, 2012
Wang, Y., Pinto, J.R., Sancho Solis, R., Dweck, D., Liang, J., Diaz-Perez, Z., Ge, Y., Walker, J.W., Potter, J.D. The Generation and Functional Characterization of Knock-In Mice Harboring the Cardiac-troponin I R21C Mutation Associated with Hypertrophic Cardiomyopathy. J. Biol. Chem. 287(3): 2156-2167, 2012
2011
Pinto, J.R., Siegfried, J.D., Parvatiyar, M.S., Li, D., Norton, N., Jones, M.A., Liang, J., Potter, J.D., Hershberger, R.E. Functional Characterization of TNNC1 Rare Variants Identified in Dilated Cardiomyopathy. J. Biol. Chem. 286(39): 34404-34412, 2011
Midde, K., Dumka, V., Pinto, J.R., Muthu, P., Marandos, P., Gryczynski, I., Gryczynski, Z., Potter, J.D., Borejdo, J. Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin T mutations. J Mol Cell Cardiol. Sep;51(3): 409-418, 2011
Pinto, J.R., Yang, S.W., Hitz, M.P., Parvatiyar, M.S., Jones, M.A., Liang, J., Victor, K., Talajic, M., Tremblay, N., Jaeggi, M., Andelfinger, G. and Potter, J.D. Fetal Cardiac Troponin Isoforms Rescue the Increased Ca2+ Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy. A Clinical, Genetic and Functional Approach. J. Biol. Chem. 286(23): 20901-20912, 2011
Pinto, J.R., Sousa, V.P. and Sorenson, M.M. Redox State of Troponin C Cysteine in the D/E Helix Alters the C-domain Affinity for the Thin Filament of Vertebrate Striated Muscle. BBA - Gen Subj. 1810(4): 391-397, 2011
Pinto, J.R., Reynaldo, D.P., Parvatiyar, M.S., Dweck, D., Liang, J., Jones, M.A., Sorenson, M.M. and Potter, J.D. Strong Crossbridges Potentiate the Ca2+ Affinity Changes Produced by HCM-Cardiac Troponin C Mutants in Myofilaments. A Fast Kinetic Approach. J. Biol. Chem. 286(2): 1005-1013, 2011
2010
Morales, A., Pinto, J.R., Siegfried, J.D., Li, D., Norton, N., Hofmeyer, M., Vallin, M., Morales, A.R., Potter, J.D. and Hershberger, R.E. Late onset sporadic dilated cardiomyopathy caused by a cardiac troponin T mutation. Clin. Trans. Sci. 3:219-226, 2010
Parvatiyar, M.S., Pinto, J.R., Liang, J.S. and Potter, J.D. Predicting Cardiomyopathic Phenotypes by Altering the Ca2+ Affinity of Cardiac Troponin C. J. Biol. Chem. 285(36): 27785-97, 2010
Li, Y., Charles, P.Y.J., Nan, C., Pinto, J.R., Wang, Y., Liang, J., Wu, G., Tian, J., Feng, H.Z., Potter, J.D., Jin, J.P. and Huang, X. Correcting diastolic dysfunction by desensitizing troponin in transgenic RCM mice. J. Mol. Cell. Card. 49: 402-411, 2010
Dweck, D., Reynaldo, D.P., Pinto, J.R. and Potter, J.D. A Dilated Cardiomyopathy Troponin C Mutation Lowers Contractile Force by Reducing Strong Myosin-Actin Binding. J. Biol. Chem. 285(23): 17371-17379, 2010
Parvatiyar, M.S., Pinto, J.R., Dweck, D. and Potter, J.D. Cardiac Troponin Mutations and Restrictive Cardiomyopathy. J. Biomed. Biotechnol. ID 350706, 2010
Willott, R.W., Gomes, A.V., Parvatiyar, M.S., Chang, A., Pinto, J.R. and Potter, J.D. Mutation in Troponin that Cause Hypertrophic, Dilated and Restrictive Cardiomyopathy: What Can We Learn About Thin Filament Function? J. Mol. Cell Card. 48: 882-892, 2010
2009
Wen, Y., Xu, Y., Wang, Y., Pinto, J.R., Potter, J.D. and Kerrick, W.G.L. Functional Effects of a Restrictive Cardiomyopathy linked Cardiac Troponin I mutation (R145W) in Transgenic Mice. J. Mol. Biol., 392(5): 1158-1167, 2009
Pinto, J.R., Parvatiyar, M.S., Jones, M.A., Liang, J., Ackerman, M.J. and Potter, J.D. A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy. J. Biol. Chem, 284(28): 19090-19100, 2009
Hershberger, R.E., Pinto, J.R., Parks, S.B., Kushner, J.D., Li, D., Ludwigsen, S., Cowan, J., Morales, A., Parvatiyar, M.S. and Potter, J.D. Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. Circulation: Cardiovasc. Genet., 2: 306-313, 2009
2008
Baudenbacher, F., Schober, T., Pinto, J.R., Sidorov, V., Hilliard, F., Solaro, R.J., Potter, J.D. and Knollmann, B.C. Myofilament Calcium Sensitization Causes Susceptibility to Cardiac Arrhythmia in Mice. J. Clin. Invest., 188(12): 3893-3903, 2008
Wen, Y., Pinto, J.R., Xu, Y., Wang, Y., Wang, Y., Gomes, A.V., Potter, J.D. and Kerrick, W.G.L. Functional Consequences of a Cardiac Troponin I (R145G) Mutation Associated with Hypertrophic Cardiomyopathy in Transgenic Mice. J. Biol. Chem., 283(29): 20484-20494, 2008
Landstrom, A.P.*, Parvatiyar, M.S.*, Pinto, J.R.*, Marquardt, M.L., Bos, J.M., Tester, D.J., Ommen, S.R., Potter, J.D. and Ackerman, M.J. Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1- Encoded Troponin C. J. Mol. Cell Card., 45: 281-288, 2008 (*Co-first author)
Pinto, J.R., Veltri, T. and Sorenson, M.M. Modulation of Troponin C Affinity for the Thin Filament by Different Types of Crossbridges in Skinned Skeletal Muscle. Pflugers Archive, 456: 1177-1187, 2008
Pinto, J.R., Parvatiyar, M.S., Jones, M.A., Liang, J. and Potter, J.D. A Troponin T Mutation that Causes Infantile Restrictive Cardiomyopathy Increases Ca2+ Sensitivity of Force Development and Impairs the Inhibitory Properties of Troponin. J. Biol. Chem. 283: 2156-2166, 2008
2006
Sousa, V.P., Pinto, J.R. and Sorenson, M.M. Ionic Interventions that Alter the Association of Troponin C C-domain with the Thin Filaments of Vertebrate Striated Muscle. Biochim. Biophys. Acta (Gen. Subj.) 1760: 272-282, 2006
Braga, C.A.C.A., Pinto, J.R., Valente, A.P., Silva, J.L., Sorenson, M.M., Foguel, D. and Suarez, M.C. Ca2+ and Mg2+ Binding to the Weak Sites of TnC C-domain Induces Exposure of a Large Hydrophobic Surface that Leads to Loss of TnC from the Thin Filament. Intl. J. Biochem. Cell Biol. 38: 110-122, 2006
2004
Costa, L.T., Pinto, J.R., Moraes, M.B., Bastos, G.G., Sorenson, M.M., Bisch, P.M. and Weissmüller, G. Chemical Treatment of Mica for Atomic Force Microscopy Can Affect Biological Sample Conformation. Biophys. Chem. 109: 63-71, 2004
