Deirdre McCarthy received her bachelor’s degree in biochemistry from University College Cork, Ireland, in 2001. She began her research at Massachusetts General Hospital, Boston, in 2002. Under the direction of Dr. Pradeep Bhide she began working on developmental neuroscience, investigating the role of dopamine in the developing mouse brain. She joined the faculty of the Department of Biomedical Sciences in 2011 to continue her research investigating a role for dopamine in mediating the effects of prenatal cocaine exposure in the developing and mature brain. In collaboration with Dr. Bhide and others, she also investigates a role of torsinA in brain development (gene associated with Early Onset Torsion Dystonia).
2001 Bachelor's degree, University of Cork, Ireland. Major: Biochemistry
Best Original Presentation Award, Annual Meeting of the National Neurotrauma Society (2002).
Member of Professional Women's Nexus
Member of the Society for Neuroscience
1. McCarthy DM, Brown AN, Bhide PG. Regulation of BDNF Expression by Cocaine. Yale Journal of Biology and Medicine 85 (2012) 437-46
2. McCarthy DM, Gioioso V, Zhang X, Sharma N, Bhide PG. Neurogenesis and Neuronal Migration in the Forebrain of the TorsinA Knockout Mouse Embryo. Dev. Neurosci., 2012; 34:366-378.
3. McCarthy DM and Bhide PG. Prenatal cocaine exposure decreases parvalbumin immunoreactive neurons and GABA-to-Projection neuron ratio in the medial prefrontal cortex. Dev. Neurosci., 2012; 34:174-183.
4. McCarthy DM, Zhang X, Darnell S, Sangrey R, Yanagawa Y, and Sadri-Vakili G, Bhide P G. Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain. J Neuroscience 2011; 31(38) 13400-13411.
5. Crandall JE, Goodman T, McCarthy DM, Duester G, Bhide PG, Dräger U, McCaffery P. Retinoic Acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. Journal of Neurochemistry 2011; 119,723-735.
6. Ren JQ; Jiang Y; Wang Z; McCarthy DM; Rajadhyaksha A; Tropea T ; Kosofsky B; Bhide PG. Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference, Neuropharmacology 2011; 60(2-3) 295-302.
7. Fujimoto K*; Araki K*; McCarthy D M*; Sims J R; Ren J Q; Zhang X; Bhide P G. A transgenic mouse model of neuroepithelial cell specific inducible overexpression of dopamine D1-receptor, Neuroscience 2010; 170(3) 961-70.
8. Balcioglu Aygul; Ren Jia-Qian; McCarthy Deirdre; Spencer Thomas J; Biederman Joseph; Bhide Pradeep G. Plasma and brain concentrations of oral therapeutic doses of methylphenidate and their impact on brain monoamine content in mice, Neuropharmacology 2009; 7 (7-8)687-693.
9. Crandall JE; McCarthy DM, Araki KY, Sims JR, Ren JQ, Bhide PG. Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex, J Neuroscience 2007; 27(14) 3813-22.
10. McCarthy DM, Lueras PM, Bhide, PG. Gestational dopamine imbalance impairs neurogenesis in specific forebrain neuroepithelial domains. Brain Research, 2007; 11820:11-25.
11. Hainsworth AH, Bermpohl D, Webb TE, Darwish R, Fiskum G, Qiu J, McCarthy D, Moskowitz MA, Whalen MJ Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J Cereb Blood Flow Metab 2005; 25:1030-1040.
12. Popolo M, McCarthy DM, Bhide PG. Influence of dopamine on precursor cell proliferation and differentiation in the embryonic mouse telencephalon. Dev. Neurosci 2004; 26:229-244.