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Pradeep Bhide Ph.D.

Professor, Jim and Betty Ann Rodgers Eminent Scholar Chair of Developmental Neuroscience, Director, Center for Brain Repair

pradeep.bhide@med.fsu.edu
(850) 645-9847
Main Campus

Biosketch

Dr. Pradeep G. Bhide is the Jim and Betty Ann Rodgers Eminent Scholar Chair of Developmental Neuroscience and the director of the Center for Brain Repair at the Florida State University College of Medicine.

Education

Dr. Bhide received his degree in veterinary medicine from Veterinary College, Bangalore, India, and a Ph.D. in neuroscience from the University of Aberdeen, Scotland. He undertook postdoctoral training in developmental neurobiology at University College, London; Yale University; and Massachusetts General Hospital and Harvard Medical School.

Service

Administrative Responsibilities
Director, Interdepartmental Neuroscience Center, Massachusetts General Hospital, Boston, MA (2003-11)
Vice Chair for Neurology Research, Massachusetts General Hospital, Boston, MA (2007-11)
Director, Center for Brain Repair, FSU College of Medicine (2011-present)
Scientific Review Committees
MDCN 7 (1999)
BDCN 2 (2003-4)
BDCN 4 (2003)
NCF/MDCN 6 (2004;2006-07)
ZNS1-SRB-E (2005-06; NINDS Program Project)
ZNS1-SRB-M34 (2006-7, NINDS Fellowships)
NINDS-NSD-B (2006; NINDS-Program Projects)
VA Center of Excellence (2009)
Neurogenesis and Cell Fate Study Section: Regular Member, 7/1/2008 – 6/30/2012
Autism Speaks, Research Grant Review Committee (2011)
MGH Subcommittee on Review of Research Proposals (2003-11)
Scientific Advisory Board National Parkinson Foundation, 2006-2008
Bryan Robinson Endowment Board, 2013-

Editorial Boards
Senior Editor, Developmental Neuroscience (2009-present)
Editorial Board - Developmental Neuroscience (2005-present)
Editorial Board: Current Neuropharmacology (2009-present)
Reviewing Editor, Frontiers in Neurogenesis (2009-present)

Honors/Awards

Charles A. King Trust Fellowship
Montreal Neurological Institute Young Investigator Award

Memberships

Society for Neuroscience

Research Focus

The research in the Bhide laboratory focuses on developmental neurological and psychiatric conditions including ADHD and early-onset generalized dystonia. Another area of research focus is the neurological and cognitive effects of prenatal and early postnatal exposure to prescription and illicit drugs.

Current research projects include examination of the role of dopamine receptor activation in the developing brain; the effects of prenatal exposure to cocaine, nicotine and analgesic medications on the development of the brain and behavior; and the developmental origins of the movement disorder generalized dystonia.

Dr. Bhide’s laboratory employs a variety of technologies including microscopy, histology, biochemistry and molecular biology, cell and tissue culture, neuropharmacology, and behavioral analysis.

Research Group

Research Faculty
Deirdre McCarthy, B.S.
Lin Zhang, M.D., Ph.D.

Graduate Students
Lataisia Jones, M.S.
Melissa Martin, M.S.

Undergraduate Students
Carlos Talledo
Matthew Williamson
Mia Tupiano

Publications

Jones, L., L. Goode, E. Davila, A. Brown, D. M. McCarthy, N. Sharma, P. G. Bhide and I. A. Armata (2017). "Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia." Biochim Biophys Acta 1863(6): 1171-1182.

Spencer, T. J., P. Bhide, J. Zhu, S. V. Faraone, M. Fitzgerald, A. M. Yule, M. Uchida, A. E. Spencer, A. M. Hall, A. J. Koster and J. Biederman (2017). "Opiate Antagonists Do Not Interfere With the Clinical Benefits of Stimulants in ADHD: A Double-Blind, Placebo-Controlled Trial of the Mixed Opioid Receptor Antagonist Naltrexone." J Clin Psychiatry.

McCarthy, D. M., G. A. Bell, E. N. Cannon, K. A. Mueller, M. N. Huizenga, G. Sadri-Vakili, D. A. Fadool and P. G. Bhide (2016). "Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model." Developmental Neuroscience 38(5): 354-364.

McCarthy, D. M., K. A. Mueller, E. N. Cannon, M. N. Huizenga, S. B. Darnell, P. G. Bhide and G. Sadri-Vakili (2016). "Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the Embryonic and Adult Brain." Developmental Neuroscience 38(5): 365-374.

Zhu, J., F. Fan, D. M. McCarthy, L. Zhang, E. N. Cannon, T. J. Spencer, J. Biederman and P. G. Bhide (2017). "A prenatal nicotine exposure mouse model of methylphenidate responsive ADHD-associated cognitive phenotypes." Int J Dev Neurosci 58: 26-34.

Zhu J, Lee KP, Spencer TJ, Biederman J, Bhide PG (2014) "Transgenerational transmission of hyperactivity in a mouse model of ADHD." The Journal of Neuroscience 34(8):2768-2773.

McCarthy DM, Gioioso V, Zhang X, Sharma N, Bhide PG (2012) "Neurogenesis and Neuronal Migration in the Forebrain of the TorsinA Knockout Mouse Embryo." Developmental Neuroscience. 34(4):366-78.

Zhu J, Zhang X, Xu Y, Spencer TJ, Biederman J, Bhide PG (2012) "Prenatal nicotine exposure mouse model showing hyperactivity, reduced cingulate cortex volume, reduced dopamine turnover and responsiveness to oral methylphenidate treatment." The Journal of Neuroscience 32:9410-8.

McCarthy DM, Bhide PG (2012) "Prenatal Cocaine Exposure Decreases Parvalbumin Immunoreactive Neurons and GABA-to-Projection Neuron Ratio in the Medial Prefrontal Cortex." Developmental Neuroscience 34:174-83.