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Jose I Diaz M.D., Ph.D.

Jose I Diaz M.D., Ph.D.

Pathology Course Director

jose.diaz@med.fsu.edu
(850) 645-8682
Main Campus

Job Description

As a Director of two Year 2 courses -- Pathology 201, which focuses mainly on the general mechanisms of diseases, and Pathology 202, which focuses mainly on specific organ diseases -- Dr. Diaz is responsible for the quality of the teaching of these two courses, including lectures, small group discussions and the clinicopathological correlation sessions. Dr Diaz is a Tenured Professor in the Department of Biomedical Sciences and a member of the Years 1 and 2 Curriculum Committee.

Biosketch

Dr Diaz joined the faculty of the University of South Florida (USF) within the Department of Pathology at the H. Lee Moffitt Cancer Center and Research Institute in Tampa (Florida) in 1991, where he served as an expert genitourinary and gastrointestinal pathologist and as a Chief of Surgical Pathology. In 2001 he joined the Florida Hospital Department of Pathology in Orlando (Florida) as a Director of Molecular Pathology. In 2002 he returned to Eastern Virginia Medical School (EVMS) in Norfolk (Virginia), where he initially trained in Pathology, as Professor and Vice Chairman of Pathology, as Director of the Anatomic and Molecular Pathology Laboratories and as a Director of Genitourinary Pathology Services and a member of the Virginia Prostate Center and the George Wright Center for Biomedical Proteomics, an internationally recognized laboratory for its contributions on serum protein profiling with mass spectrometry for the early detection of prostate cancer. In 2006 he joined the faculty of the Cancer Therapy Research Center’s (CTRC) Institute for Drug Development (IDD) at the University of Texas in San Antonio (Texas), where he served as a Chairman of the Division of Molecular Pathology and Director of the Molecular Oncology Targeted Therapy Program. In the summer of 2008 Dr. Diaz joined the faculty of the Florida State University College of Medicine (FSUCOM) to continue his career with a new focus on medical education in Pathology. While still serving as full-time faculty at FSUCOM, in the summer of 2010 Dr Diaz became the Medical Director for the Pathology Laboratory at the Tallahassee Endoscopy Center-Digestive Disease Clinic. Dr. Diaz is an accomplished genitourinary pathologist and has published extensively on this field. He is a diplomate of the American Board of Pathology in both Anatomic and Clinical Pathology. He is also one of the first and few US pathologists certified on “Molecular Genetic Pathology” by the American Boards of Pathology and Medical Genetics. He is married to Inmaculada Silverio and has two children: Igancio Diaz-Silverio and Sergio Diaz-Silverio.

Education

Dr Diaz obtained his MD and PhD from the Autonoma University of Madrid College of Medicine (Spain) in 1982 and 2000, respectively. In 1983 he moved to the U.S.A. as a fellow in Reproductive Endocrinology at the Jones Institute for Reproductive Medicine in Norfolk (Virginia). The first sucessful "Human In Vitro Fertilization" attempt in America was achived at this institution in 1983. This was the third sucessful attempt in the world after the first two in England and Australia, respectively. In 1986 he began a new career in Cancer Research completing his training in Anatomic Pathology at EVMS and subsequently, a fellowship in Surgical Pathology and a Residency in Clinical Pathology at the Cleveland Clinic Foundation in Cleveland (Ohio). In 1993 while being faculty at USF, he took a sabbatical to train in Molecular Genetic Pathology at the New England Medical Center (Tufts University) in Boston (Massachusetts).

Service

Dr. Diaz has been co-investigator on multiple NIH/NCI and DOD sponsored grants and has presented numerous didactic and research seminars nationally and internationally. He is member of the Editorial Board of Frontiers in Bioscience and Reviewer for the Journal of Urology. He has served in many Hospital, University and National Committees, including: 1) South Western Oncology Group Genitourinary Committee, Translational Medicine Subcommittee, 2) Inspector for the College of American Pathologist’s Laboratory Accreditation Program in Anatomic, Clinical and Molecular Pathology, 3 Pediatric Oncology Group, 4) South Western Oncology Group: Hematopathology Subcommittee. Dr Diaz is currently a member of the Group of Research in Pathology Education (GRIPE), a national organization of educators in the field of Pathology represented by most medical medical schools in the USA. He serves as a member and was the previous Chair of the “Team Based Learning” Committee until the summer of 2012.

Honors/Awards

Cleveland Clinic Foundation "William E. Lower" Fellowship Thesis Award; First Prize: Basic Sciences (1990).
Doctoral Thesis Summa Cum laude with Highest Honors, Autonoma University of Madrid College of Medicine (2000).
Pathology Resident Competition Award for Scientific Papers; Second Prize. Cleveland Society of Pathologists (1990).
Summa Cum Laude with Highest Honors in Biochemistry, Institute of Enzymology of the Autonoma University of Madrid College of Medicine (1977).

Memberships

1. Group of Research in Pathology Education. 2. National Cancer Institute’s Early Detection Research Network. 3. College of American Pathologists. 4. United States and Canadian Academy of Pathology 5. American Urological Association 6. Association of Molecular Pathologists 7. South Western Oncology Group

Research Focus

1. Molecular pathogenesis of cancer with special interest on genitourinary malignancies, 2. Pathobiology of cancer stem cells, 3. Molecularly defined cancer targeted therapy,

Publications

Most Recent Articles and Book Chapters

Cazares, L. H., Diaz, J. I., Drake, R. R., & Semmes, O. J. (2008). MALDI/SELDI protein profiling of serum for the identification of cancer biomarkers. Methods Mol Biol, 428, 125-40.

Diaz, J. I., Cazares, L. H., & Semmes, O. J. (2008). Tissue sample collection for proteomics analysis. Methods Mol Biol, 428, 43-53.

Garbis, S., Tyritzis, S., Roumeliotis, T., Pavlakis, K., Zerefos, P., Diaz, J. I., Giannopoulou, E., Vlahou, A., Kossida, S., & Vourekas, S. (2008). Search for Potential Markers for Prostate Cancer Diagnosis, Prognosis, and Treatment in Clinical Tissue Specimens Using Amin-Specific Isobaric Tagging with Tow Dimentional Liquid Chromatography and Tandem Mass Spectrometry. The Journal of Proteome Research, 7, 3146-3158.

Tamvakopoulos, C., Sanoudou, D., Costantinides, CA., McLerran, D., Grizzle, W., Feng, Z., Bigbee, W., Banez, L., Cazares, L., Chan, D., Diaz, J. I., Izbicka, E., & Kagan, J. (2008). Analytical Validation of Protein Expression Profiling for the Diagnosis of Prostatic Carcinoma; Sources of Sample Bias. Clin Chem, 54(1), 44-52.

Malik, G., Oelschlager, D., Partin, A., Randolph, T., Rosenzweig, N., Srivastava, Sh., Srivastava, Su., Thompson, I., Thornquist, M., Troyer, D., Yasui, Y., Zhang, Z., Zhu, L., Semmes, O. McLerran, D., Grizzle, W., Feng, Z., Thompson, I., Bigbee, W., Cazares, L., Chan, D., Diaz, J. I., Dahlgren, J., & Kagan, J. (2008). SELDI-TOF-MS Serum Protein Profiling does not Reliably Detect Prostate Cancer. Clin. Chem, 54(1), 53-60.

Lin, D., Malik, G., Oelschlager, D., Partin, A., Randolph, T., Sokoll, L., Semmes, OJ. Diaz JI, Cazares L and Semmes OJ: Tissue Processing for Proteomics Analysis in METHODS IN MOLECULAR BIOLOGY vol. 428: Clinical Proteomics: Methods and Protocols 2007; 3: 43-53. Vlahou A; Ed. Humana Press, Totowa, NJ.

Cazares L, Diaz JI, Drake RR and Semmes OJ: MALDI/SELDI Protein Chip Profiling of Serum for the Identification of Cancer Biomarkers, in METHODS IN MOLECULAR BIOLOGY vol. 428: Clinical Proteomics: Methods and Protocols 2007; 7: 125-140. Vlahou A; Ed. Humana Press, Totowa, NJ.

McLerran D, Grizzle W, Feng Z, Bigbee W, Banez L, Cazares L, Chan D, Diaz J, Izbicka E, Kagan J, Malik G, Oelschlager D, Partin A, Randolph T, Rosenzweig N, Srivastava Sh, Srivastava Su, Thompson I, Thornquist M, Troyer D, Yasui Y, Zhang Z, Zhu L, and Semmes O.: Analytical Validation of Protein Expression Profiling for the Diagnosis of Prostatic Carcinoma; Sources of Sample Bias. Clin Chem 2008; 54 (1): 44-52.

McLerran D, Grizzle W, Feng Z, Thompson I, Bigbee W, Cazares L, Chan D, Dahlgren J, Diaz J, Kagan J, Lin D, Malik G, Oelschlager D, Partin A, Randolph T, Sokoll L, Srivastava Sh, Srivastava Su, Thornquist M, Troyer D, Yasui Y, Zhang Z, Zhu L, and Semmes OJ.: SELDI-TOF-MS Serum Protein Profiling does not Reliably Detect Prostate Cencer. Clin Chem 2008; 54 (1): 53-60.

Garbis SD, Tyritzis SI, Roumeliotis T, Pavlakis K, Zerefos P, Giannopoulou EG, Vlahou A, Kossida S, Diaz, JI, Vourekas S, Tamvakopoulos C, Sanoudou D, Constantinides CA.: Search for Potential Markers for Prostate Cancer Diagnosis, Prognosis and Treatment in Clinical Tissue Specimens Using Amin-Specific Isobaric Tagging (iTRAQ) with Tow-Dimentional Liquid Chromatography and Tandem Mass Spectometry. The Journal of Proteome Research 2008; 7: 3146-3158.

Schellhammer P, Diaz J, Fabrizio M, Davis J, Given R, Main B, Chaganty N, Hussein R and McKenzie R.: Computer Modeling Technology to Assess Extra-Capsular Tissue Coverage of Whole Mount Sections after Retropubic and Laparoscopic Radical Prostatectomy. J of Urology 2207; 178: 1301-1305.

Drake RR, Schwegler EE, Malik G, Diaz JI, Block T, Mehta A, and Semmes OJ.: Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. Mol and Cell Proteomics 2006; 5: 1957-1967.

Yang H, Wen YY, Zhao R, Lin YL Fournier K, Yang HY, Qui Y, Diaz J, Laronga C, Lee MH.: DNA Damage-Induced Protein 14-3-3 Sigma Inhibits Protein Kinase B/ Akt Activation and Suppresses Akt-Activated Cancer. Cancer Research 2006; 66 (6): 3096-3015.

Yang H, Zhang Y, Zhao R, Wen Y-Y, Fournier K, Wu H-B, Yang H-Y, Diaz J, Laronga C, Lee M-H.: Negative Cell Cycle Regulator 14-3-3 Sigma Stabilizes p27/Kip1 by Inhibiting the Activity of PKB/Akt. Oncogene 2006; 25 (33): 4585-4594.

Holterman D, Diaz J, Blackmore P, Davis J, Schellhammer P, Corica A, Semmes J and Vlahou A.: Over-expression of a-Defensin is Associated with Bladder Cancer Invasiveness. Urologic Oncology 2006; 24 (2): 97-108.

Soderdahl D, Diaz J, Raba D, Schellhammer P and Fabrizio M.: Laparoscopic radical prostatectomy: evaluation of specimen pathologic features to critically assess and modify surgical technique. Urology 2005; 66(3): 552-556.

Mirkin S, Arslan M, Chrurikov D, Corica A, Diaz J, Williams S, Bocca S and Oehninger S.: In search of candidate genes critically expressed in human endometrium during the window of implantation. Human Reproduction 2005; 20 (8): 2104-2117.

Malik G., Ward MD, Grizzle WE, Adam BL, Diaz J and Semmes OJ.: Serum levels of an Isoform of Apolipoprotein A-II as a Potential Marker for Prostate Cancer. Clinical Cancer Research 2005; 11(3): 1073-1085.

Mirkin S, Nikas G, Hsiu JG, Diaz J and Oehninger S.: Gene Expression Profiles and Structural/Functional Features of the Peri-Implantation Endometrium in Natural and Gonadotropin-Stimulated Cycles. J of Clin Endocrinol and Metabol 2004; 89(11): 5742-5752.

Diaz J, Cazares LH, Corica A and Semmes O.: Selective Capture of Prostatic Basal Cells and Secretory Epithelial Cells for Proteomic and Genomic Analysis. Urol Oncol 2004; 22 (4): 329-326.