Birth and Death of Histone mRNAs: Life Without a polyA Tail
| Start Date: | 10/10/2012 |
|---|---|
| End Date: | 10/10/2012 |
| Start Time: | 12:00 pm |
| End Time: | 1:00 pm |
| Location: | FSU College of Medicine Room 1306 |
| Area: | Central Campus |
| City: | Tallahassee |
| State: | Florida |
| Event Type: | Seminar |
| Event Host: | FSU College of Medicine Dept. of Biomedical Sciences |
| Introduction: | Presenter: William F. Marzluff, Ph.D. |
| Description: | Histone mRNAs are the only eukaryotic mRNAs that don’t have a polyA tail. Histone mRNAs are expressed only in S-phase, and most of the regulation is posttranscriptional, regulating both pre-mRNA processing and mRNA degradation. Since there is a stem-loop rather than a polyA tail at the 3’ end of the mRNA, a separate set of machinery has evolved to deal for the processing, translation and degradation of histone mRNA. These include SLBP, which binds the stemloop and participates in all aspects of histone mRNA metabolism, a subset of the polyadenylation factors that are required for processing of histone pre-mRNA and a novel modification of the 3’ end of histone mRNA that is required for its degradation |
| Contact Name: | Daettia Butler |
| Contact Email: | daettia.butler@med.fsu.edu |
| Contact Phone: | 850-644-4934 |
